The role of cytokines in physiological sleep regulation

James M. Krueger, Ferenc Obál, Jidong Fang, Takeshi Kubota, Ping Taishi

Research output: Contribution to journalArticle

283 Citations (Scopus)

Abstract

Several growth factors (GFs) are implicated in sleep regulation. It is posited that these Gfs are produced in response to neural activity and affect input-output relationships within the neural circuits where they are produced, thereby inducing a local state shift. These Gfs also influence synaptic efficacy. All the Gfs currently identified as sleep regulatory substances are also implicated in synaptic plasticity. Among these substances, the most extensively studied for their role in sleep regulation are interleukin-1β (IL-1) and tumor necrosis factor α (TNF). Injection of IL-1 or TNF enhances non-rapid eye movement sleep (NREMS). Inhibition of either IL-1 or TNF inhibits spontaneous sleep and the sleep rebound that occurs after sleep deprivation. Stimulation of the endogenous production of IL-1 and TNF enhances NREMS. Brain levels of IL-1 and TNF correlate with sleep propensity; for example, after sleep deprivation, their levels increase. IL-1 and TNF are part of a complex biochemical cascade regulating sleep. Downstream events include nitric oxide, growth hormone releasing hormone, nerve growth factor, nuclear factor kappa B, and possibly adenosine and prostaglandins. Endogenous substances moderating the effects of IL-1 and TNF include anti-inflammatory cytokines such as IL-4, IL-10, and IL-13. Clinical conditions altering IL-1 or TNF activity are associated with changes in sleep, for example, infectious disease and sleep apnea. As our knowledge of the biochemical regulation of sleep progresses, our understanding of sleep function and of many clinical conditions will improve.

Original languageEnglish (US)
Pages (from-to)211-221
Number of pages11
JournalAnnals of the New York Academy of Sciences
Volume933
StatePublished - Jan 1 2001

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Sleep
Cytokines
Interleukin-1
Tumor Necrosis Factor-alpha
Sleep Deprivation
Eye Movements
Eye movements
Growth Hormone-Releasing Hormone
Neuronal Plasticity
Interleukin-13
NF-kappa B
Sleep Apnea Syndromes
Nerve Growth Factor
Interleukin-4
Interleukin-10
Adenosine
Prostaglandins
Communicable Diseases
Intercellular Signaling Peptides and Proteins
Nitric Oxide

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • History and Philosophy of Science

Cite this

Krueger, J. M., Obál, F., Fang, J., Kubota, T., & Taishi, P. (2001). The role of cytokines in physiological sleep regulation. Annals of the New York Academy of Sciences, 933, 211-221.
Krueger, James M. ; Obál, Ferenc ; Fang, Jidong ; Kubota, Takeshi ; Taishi, Ping. / The role of cytokines in physiological sleep regulation. In: Annals of the New York Academy of Sciences. 2001 ; Vol. 933. pp. 211-221.
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Krueger, JM, Obál, F, Fang, J, Kubota, T & Taishi, P 2001, 'The role of cytokines in physiological sleep regulation', Annals of the New York Academy of Sciences, vol. 933, pp. 211-221.

The role of cytokines in physiological sleep regulation. / Krueger, James M.; Obál, Ferenc; Fang, Jidong; Kubota, Takeshi; Taishi, Ping.

In: Annals of the New York Academy of Sciences, Vol. 933, 01.01.2001, p. 211-221.

Research output: Contribution to journalArticle

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