The Role of Donor Lymphocyte Infusion (DLI) in Post-Hematopoietic Cell Transplant (HCT) Relapse for Chronic Myeloid Leukemia (CML) in the Tyrosine Kinase Inhibitor (TKI) Era: Role of DLI in Post-HCT Relapse for CML in the TKI Era

Sarah Schmidt, Ying Liu, Zhen Huan Hu, Kirsten M. Williams, Hillard M. Lazarus, Ravi Vij, Mohamed A. Kharfan-Dabaja, Guillermo Ortí, Peter H. Wiernik, Daniel Weisdorf, Rammurti T. Kamble, Roger Herzig, Baldeep Wirk, Jan Cerny, Ulrike Bacher, Naeem A. Chaudhri, Sunita Nathan, Nosha Farhadfar, Mahmoud Aljurf, Usama GergisJeffrey Szer, Sachiko Seo, Jack W. Hsu, Richard F. Olsson, Dipnarine Maharaj, Biju George, Gerhard C. Hildebrandt, Vaibhav Agrawal, Taiga Nishihori, Hisham Abdel-Azim, Edwin Alyea, Uday Popat, Ronald Sobecks, Bart L. Scott, Jennifer Holter Chakrabarty, Wael Saber

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

Treatment for relapse of chronic myeloid leukemia (CML) following hematopoietic cell transplantation (HCT) includes tyrosine kinase inhibitors (TKIs) with or without donor lymphocyte infusions (DLIs), but the most effective treatment strategy is unknown. This study was performed through the Center for International Blood and Marrow Transplant Research (CIBMTR) database. We retrospectively reviewed all patients reported to the CIBMTR registry from 2002 to 2014 who underwent HCT for CML and were alive 30 days postrelapse. A total of 215 HCT recipients relapsed and were analyzed in the following groups: (1) TKI alone (n = 128), (2) TKI with DLI (n = 48), and (3) DLI without TKI (n = 39). In multivariate analysis, disease status prior to HCT had a significant effect on overall survival (OS). Patients who received a DLI alone compared with a TKI with a DLI had inferior survival (hazard ratio, 2.28; 95% confidence interval, 1.23 to 4.24; P= .009). Those who received a TKI alone had similar survival compared with those who received a TKI with a DLI (P = .81). These data support that despite use of TKIs pretransplantation, TKI salvage therapy continues to provide significant survival following relapse in patients with CML following HCT. These data do not suggest that adding a DLI to a TKI adds an improvement in OS.

Original languageEnglish (US)
Pages (from-to)1137-1143
Number of pages7
JournalBiology of Blood and Marrow Transplantation
Volume26
Issue number6
DOIs
StatePublished - Jun 2020

All Science Journal Classification (ASJC) codes

  • Hematology
  • Transplantation

Fingerprint Dive into the research topics of 'The Role of Donor Lymphocyte Infusion (DLI) in Post-Hematopoietic Cell Transplant (HCT) Relapse for Chronic Myeloid Leukemia (CML) in the Tyrosine Kinase Inhibitor (TKI) Era: Role of DLI in Post-HCT Relapse for CML in the TKI Era'. Together they form a unique fingerprint.

Cite this