ICAM-1 ve polymorfonötrofil ligandi olan fibrin molekülü nün deǧişen akiş koşullarinda melanoma adhezyonuna etkisi

Translated title of the contribution: The role of fibrin as a ligand for ICAM-1 and PMN in melanoma adhesion under different shear conditions

Tuǧba Özdemir, Cheng Dong

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

One of the predominant cause of cancer patient death is the metastatic spread of tumor cells. The leading step in melanoma extravasation is the tumor cell adhesion to the endothelium of the capillaries. However, melanoma cells do not express the appropriate adhesion molecules to bind to an activated endothelium. Previous studies have found neutrophils facilitate melanoma cell adhesion under dynamic flow conditions throught the binding of ICAM-1 on melanoma cells and β 2 integrins on PMNs. In addition, soluble fibrin (sFn) is a marker for propagated intravascular coagulation and have a dramatical increase in cancer patients' laboratory coagulation inspections . Soluble fibrin molecule has both receptors for Mac-1 on PMNs and ICAM-1 on tumor cell surface which may affect the tumor cell adherence to endothelial wall surface via PMN. The objective of this study is to investigate the role of soluble fibrin on PMN facilitated tumor cell adherence to endothelial wall and how different effects of hydrodynamic shear stress and shear rate affects the force of adhesion to vessel wall.

Translated title of the contributionThe role of fibrin as a ligand for ICAM-1 and PMN in melanoma adhesion under different shear conditions
Original languageTurkish
Title of host publicationProceedings of 2009 14th National Biomedical Engineering Meeting, BIYOMUT 2009
DOIs
StatePublished - Oct 27 2009
Event2009 14th National Biomedical Engineering Meeting, BIYOMUT 2009 - Balcova, Izmir, Turkey
Duration: May 20 2009May 22 2009

Publication series

NameProceedings of 2009 14th National Biomedical Engineering Meeting, BIYOMUT 2009

Conference

Conference
CountryTurkey
CityBalcova, Izmir
Period5/20/095/22/09

All Science Journal Classification (ASJC) codes

  • Biomedical Engineering
  • Pharmacology (medical)
  • Radiology Nuclear Medicine and imaging

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    Özdemir, T., & Dong, C. (2009). ICAM-1 ve polymorfonötrofil ligandi olan fibrin molekülü nün deǧişen akiş koşullarinda melanoma adhezyonuna etkisi. In Proceedings of 2009 14th National Biomedical Engineering Meeting, BIYOMUT 2009 [5130385] (Proceedings of 2009 14th National Biomedical Engineering Meeting, BIYOMUT 2009). https://doi.org/10.1109/BIYOMUT.2009.5130385