The role of gender in heart transplantation

Thomas W. Prendergast, Satoshi Furukawa, A. James Beyer, Barry J. Browne, Howard J. Eisen, Valluvan Jeevanandam

Research output: Contribution to journalArticlepeer-review

84 Scopus citations

Abstract

Background. The effect of donor and recipient gender on the outcome of heart transplantation (HT) remains uncertain. Methods. One hundred seventy- four patients who underwent HT were divided into four groups according to donor and recipient gender. Group A consisted of 81 men who received male donor hearts, group B of 18 women who received female donor hearts, group C of 21 women who received male donor hearts, and group D of 54 men who received female donor hearts. All patients were treated by the same group of surgeons according to standard HT protocols. Comparisons were made between groups with regard to short- and long-term outcomes. Results. Donor gender and recipient gender did not affect outcomes significantly. Overall, donor- recipient gender mismatching significantly increased the number of rejection episodes and reduced creatinine clearance, survival, and censored survival in the first year after HT (p < 0.05). More specifically, among female recipients, donor-recipient gender mismatching significantly increased the number of rejection episodes and decreased creatinine clearance in the first year after HT (p < 0.05); among male recipients, donor-recipient gender mismatching significantly reduced 1-year survival and censored survival to date after HT (p < 0.05). Conclusions. Donor-recipient gender matching plays a significant role in determining HT outcomes.

Original languageEnglish (US)
Pages (from-to)88-94
Number of pages7
JournalAnnals of Thoracic Surgery
Volume65
Issue number1
DOIs
StatePublished - Jan 1998

All Science Journal Classification (ASJC) codes

  • Surgery
  • Pulmonary and Respiratory Medicine
  • Cardiology and Cardiovascular Medicine

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