The role of growth factors and proteins in media for in vitro fertilization

J. Moessner, William Dodson

Research output: Contribution to journalReview article

3 Citations (Scopus)

Abstract

Despite new developments and techniques over the past decade, pregnancy rates for IVF-ET still average only 22%. The quality of the environment in which the pre-embryos develop has a major impact on the viability of the cells. In an effort to mimic the optimal in vivo conditions, various media supplements such as sera, albumin, follicular fluid, amniotic fluid, growth factors, and helper cells have been used. The results with cocultures are very encouraging, suggesting that growth factors secreted by the reproductive tract may play an important role in pre-embryo development. It is the definition and simulation of the beneficial environment furnished by the normal fallopian tube that will allow us to provide ideal pregnancy rates to our infertile patients.

Original languageEnglish (US)
Pages (from-to)63-67
Number of pages5
JournalAssisted Reproduction Reviews
Volume3
Issue number2
StatePublished - 1993

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Pregnancy Rate
Fertilization in Vitro
Intercellular Signaling Peptides and Proteins
Follicular Fluid
Fallopian Tubes
Amniotic Fluid
Helper-Inducer T-Lymphocytes
Coculture Techniques
Serum Albumin
Embryonic Development
Cell Survival
Proteins
Embryonic Structures

All Science Journal Classification (ASJC) codes

  • Obstetrics and Gynecology

Cite this

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abstract = "Despite new developments and techniques over the past decade, pregnancy rates for IVF-ET still average only 22{\%}. The quality of the environment in which the pre-embryos develop has a major impact on the viability of the cells. In an effort to mimic the optimal in vivo conditions, various media supplements such as sera, albumin, follicular fluid, amniotic fluid, growth factors, and helper cells have been used. The results with cocultures are very encouraging, suggesting that growth factors secreted by the reproductive tract may play an important role in pre-embryo development. It is the definition and simulation of the beneficial environment furnished by the normal fallopian tube that will allow us to provide ideal pregnancy rates to our infertile patients.",
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The role of growth factors and proteins in media for in vitro fertilization. / Moessner, J.; Dodson, William.

In: Assisted Reproduction Reviews, Vol. 3, No. 2, 1993, p. 63-67.

Research output: Contribution to journalReview article

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T1 - The role of growth factors and proteins in media for in vitro fertilization

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AU - Dodson, William

PY - 1993

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