Abstract

Cortical oscillations arise during behavioral and mental tasks, and all temporal oscillations have particular spatial patterns. Studying the mechanisms that generate and modulate the spatiotemporal characteristics of oscillations is important for understanding neural information processing and the signs and symptoms of dynamical diseases of the brain. Nevertheless, it remains unclear how GABAergic inhibition modulates these oscillation dynamics. Using voltage-sensitive dye imaging, pharmacological methods, and tangentially cut occipital neocortical brain slices (including layers 3-5) of Sprague-Dawley rat, we found that GABAa disinhibition with bicuculline can progressively simplify oscillation dynamics in the presence of carbachol in a concentration-dependent manner. Additionally, GABAb disinhibition can further simplify oscillation dynamics after GABAa receptors are blocked. Both GABAa and GABAb disinhibition increase the synchronization of the neural network. Theta frequency (5-15-Hz) oscillations are reliably generated by using a combination of GABAa and GABAb antagonists alone. These theta oscillations have basic spatiotemporal patterns similar to those generated by carbachol/bicuculline. These results are illustrative of how GABAergic inhibition increases the complexity of patterns of activity and contributes to the regulation of the cortex. Cortical oscillations arise during behavioral and mental tasks, and all temporal oscillations have particular spatial patterns. Studying the mechanisms that generate and modulate the spatiotemporal characteristics of oscillations is important for understanding neural information processing and the signs and symptoms of dynamical diseases of the brain.

Original languageEnglish (US)
Pages (from-to)2201-2212
Number of pages12
JournalEuropean Journal of Neuroscience
Volume36
Issue number2
DOIs
StatePublished - Jul 1 2012

Fingerprint

Bicuculline
Carbachol
Brain Diseases
Automatic Data Processing
Signs and Symptoms
Voltage-Sensitive Dye Imaging
Sprague Dawley Rats
Pharmacology
Brain

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)

Cite this

Xiao, Ying ; Huang, Xiao ying ; Van Wert, Stephen ; Barreto, Ernest ; Wu, Jian young ; Gluckman, Bruce J. ; Schiff, Steven J. / The role of inhibition in oscillatory wave dynamics in the cortex. In: European Journal of Neuroscience. 2012 ; Vol. 36, No. 2. pp. 2201-2212.
@article{bdd2db50b5d8481594e3e83fe3485b74,
title = "The role of inhibition in oscillatory wave dynamics in the cortex",
abstract = "Cortical oscillations arise during behavioral and mental tasks, and all temporal oscillations have particular spatial patterns. Studying the mechanisms that generate and modulate the spatiotemporal characteristics of oscillations is important for understanding neural information processing and the signs and symptoms of dynamical diseases of the brain. Nevertheless, it remains unclear how GABAergic inhibition modulates these oscillation dynamics. Using voltage-sensitive dye imaging, pharmacological methods, and tangentially cut occipital neocortical brain slices (including layers 3-5) of Sprague-Dawley rat, we found that GABAa disinhibition with bicuculline can progressively simplify oscillation dynamics in the presence of carbachol in a concentration-dependent manner. Additionally, GABAb disinhibition can further simplify oscillation dynamics after GABAa receptors are blocked. Both GABAa and GABAb disinhibition increase the synchronization of the neural network. Theta frequency (5-15-Hz) oscillations are reliably generated by using a combination of GABAa and GABAb antagonists alone. These theta oscillations have basic spatiotemporal patterns similar to those generated by carbachol/bicuculline. These results are illustrative of how GABAergic inhibition increases the complexity of patterns of activity and contributes to the regulation of the cortex. Cortical oscillations arise during behavioral and mental tasks, and all temporal oscillations have particular spatial patterns. Studying the mechanisms that generate and modulate the spatiotemporal characteristics of oscillations is important for understanding neural information processing and the signs and symptoms of dynamical diseases of the brain.",
author = "Ying Xiao and Huang, {Xiao ying} and {Van Wert}, Stephen and Ernest Barreto and Wu, {Jian young} and Gluckman, {Bruce J.} and Schiff, {Steven J.}",
year = "2012",
month = "7",
day = "1",
doi = "10.1111/j.1460-9568.2012.08132.x",
language = "English (US)",
volume = "36",
pages = "2201--2212",
journal = "European Journal of Neuroscience",
issn = "0953-816X",
publisher = "Wiley-Blackwell",
number = "2",

}

The role of inhibition in oscillatory wave dynamics in the cortex. / Xiao, Ying; Huang, Xiao ying; Van Wert, Stephen; Barreto, Ernest; Wu, Jian young; Gluckman, Bruce J.; Schiff, Steven J.

In: European Journal of Neuroscience, Vol. 36, No. 2, 01.07.2012, p. 2201-2212.

Research output: Contribution to journalArticle

TY - JOUR

T1 - The role of inhibition in oscillatory wave dynamics in the cortex

AU - Xiao, Ying

AU - Huang, Xiao ying

AU - Van Wert, Stephen

AU - Barreto, Ernest

AU - Wu, Jian young

AU - Gluckman, Bruce J.

AU - Schiff, Steven J.

PY - 2012/7/1

Y1 - 2012/7/1

N2 - Cortical oscillations arise during behavioral and mental tasks, and all temporal oscillations have particular spatial patterns. Studying the mechanisms that generate and modulate the spatiotemporal characteristics of oscillations is important for understanding neural information processing and the signs and symptoms of dynamical diseases of the brain. Nevertheless, it remains unclear how GABAergic inhibition modulates these oscillation dynamics. Using voltage-sensitive dye imaging, pharmacological methods, and tangentially cut occipital neocortical brain slices (including layers 3-5) of Sprague-Dawley rat, we found that GABAa disinhibition with bicuculline can progressively simplify oscillation dynamics in the presence of carbachol in a concentration-dependent manner. Additionally, GABAb disinhibition can further simplify oscillation dynamics after GABAa receptors are blocked. Both GABAa and GABAb disinhibition increase the synchronization of the neural network. Theta frequency (5-15-Hz) oscillations are reliably generated by using a combination of GABAa and GABAb antagonists alone. These theta oscillations have basic spatiotemporal patterns similar to those generated by carbachol/bicuculline. These results are illustrative of how GABAergic inhibition increases the complexity of patterns of activity and contributes to the regulation of the cortex. Cortical oscillations arise during behavioral and mental tasks, and all temporal oscillations have particular spatial patterns. Studying the mechanisms that generate and modulate the spatiotemporal characteristics of oscillations is important for understanding neural information processing and the signs and symptoms of dynamical diseases of the brain.

AB - Cortical oscillations arise during behavioral and mental tasks, and all temporal oscillations have particular spatial patterns. Studying the mechanisms that generate and modulate the spatiotemporal characteristics of oscillations is important for understanding neural information processing and the signs and symptoms of dynamical diseases of the brain. Nevertheless, it remains unclear how GABAergic inhibition modulates these oscillation dynamics. Using voltage-sensitive dye imaging, pharmacological methods, and tangentially cut occipital neocortical brain slices (including layers 3-5) of Sprague-Dawley rat, we found that GABAa disinhibition with bicuculline can progressively simplify oscillation dynamics in the presence of carbachol in a concentration-dependent manner. Additionally, GABAb disinhibition can further simplify oscillation dynamics after GABAa receptors are blocked. Both GABAa and GABAb disinhibition increase the synchronization of the neural network. Theta frequency (5-15-Hz) oscillations are reliably generated by using a combination of GABAa and GABAb antagonists alone. These theta oscillations have basic spatiotemporal patterns similar to those generated by carbachol/bicuculline. These results are illustrative of how GABAergic inhibition increases the complexity of patterns of activity and contributes to the regulation of the cortex. Cortical oscillations arise during behavioral and mental tasks, and all temporal oscillations have particular spatial patterns. Studying the mechanisms that generate and modulate the spatiotemporal characteristics of oscillations is important for understanding neural information processing and the signs and symptoms of dynamical diseases of the brain.

UR - http://www.scopus.com/inward/record.url?scp=84864000932&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84864000932&partnerID=8YFLogxK

U2 - 10.1111/j.1460-9568.2012.08132.x

DO - 10.1111/j.1460-9568.2012.08132.x

M3 - Article

C2 - 22805065

AN - SCOPUS:84864000932

VL - 36

SP - 2201

EP - 2212

JO - European Journal of Neuroscience

JF - European Journal of Neuroscience

SN - 0953-816X

IS - 2

ER -