The role of irreversible EGFR inhibitors in the treatment of non-small cell lung cancer: Overcoming resistance to reversible EGFR inhibitors

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Abstract

Reversible epidermal growth factor receptor tyrosine kinase inhibitors are often used for the treatment of non-small cell lung cancer following failure of cytotoxic chemotherapy. While these agents are active in a subset of patients, most develop resistance and progress within the course of 1 year. In nearly half of the cases, acquired resistance is caused by a secondary epidermal growth factor receptor T790M mutation. Irreversible epidermal growth factor receptor tyrosine kinase inhibitors are an emerging class of agents that may have the potential to overcome and prevent the emergence of such mutation-related resistance.

Original languageEnglish (US)
Pages (from-to)413-423
Number of pages11
JournalCancer Investigation
Volume28
Issue number4
DOIs
Publication statusPublished - Apr 1 2010

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All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

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