The role of mass spectrometry-based metabolomics in medical countermeasures against radiation

Andrew D. Patterson, Christian Lanz, Frank J. Gonzalez, Jeffrey R. Idle

Research output: Contribution to journalArticle

38 Citations (Scopus)

Abstract

Radiation metabolomics can be defined as the global profiling of biological fluids to uncover latent, endogenous small molecules whose concentrations change in a dose-response manner following exposure to ionizing radiation. In response to the potential threat of nuclear or radiological terrorism, the Center for High-Throughput Minimally Invasive Radiation Biodosimetry was established to develop field-deployable biodosimeters based, in part, on rapid analysis by mass spectrometry of readily and easily obtainable biofluids. In this review, we briefly summarize radiation biology and key events related to actual and potential nuclear disasters, discuss the important contributions the field of mass spectrometry has made to the field of radiation metabolomics, and summarize current discovery efforts to use mass spectrometry-based metabolomics to identify dose-responsive urinary constituents, and ultimately to build and deploy a noninvasive highthroughput biodosimeter.

Original languageEnglish (US)
Pages (from-to)503-521
Number of pages19
JournalMass Spectrometry Reviews
Volume29
Issue number3
DOIs
StatePublished - May 1 2010

Fingerprint

Metabolomics
countermeasures
Mass spectrometry
Mass Spectrometry
mass spectroscopy
Radiation
radiation
Radiobiology
Terrorism
Disasters
terrorism
Ionizing Radiation
nuclear potential
dosage
disasters
Ionizing radiation
biology
ionizing radiation
Dosimetry
Throughput

All Science Journal Classification (ASJC) codes

  • Analytical Chemistry
  • Condensed Matter Physics
  • Biochemistry, Genetics and Molecular Biology(all)
  • Spectroscopy

Cite this

Patterson, Andrew D. ; Lanz, Christian ; Gonzalez, Frank J. ; Idle, Jeffrey R. / The role of mass spectrometry-based metabolomics in medical countermeasures against radiation. In: Mass Spectrometry Reviews. 2010 ; Vol. 29, No. 3. pp. 503-521.
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The role of mass spectrometry-based metabolomics in medical countermeasures against radiation. / Patterson, Andrew D.; Lanz, Christian; Gonzalez, Frank J.; Idle, Jeffrey R.

In: Mass Spectrometry Reviews, Vol. 29, No. 3, 01.05.2010, p. 503-521.

Research output: Contribution to journalArticle

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