The role of mass spectrometry-based metabolomics in medical countermeasures against radiation

Andrew D. Patterson, Christian Lanz, Frank J. Gonzalez, Jeffrey R. Idle

Research output: Contribution to journalArticle

39 Scopus citations

Abstract

Radiation metabolomics can be defined as the global profiling of biological fluids to uncover latent, endogenous small molecules whose concentrations change in a dose-response manner following exposure to ionizing radiation. In response to the potential threat of nuclear or radiological terrorism, the Center for High-Throughput Minimally Invasive Radiation Biodosimetry was established to develop field-deployable biodosimeters based, in part, on rapid analysis by mass spectrometry of readily and easily obtainable biofluids. In this review, we briefly summarize radiation biology and key events related to actual and potential nuclear disasters, discuss the important contributions the field of mass spectrometry has made to the field of radiation metabolomics, and summarize current discovery efforts to use mass spectrometry-based metabolomics to identify dose-responsive urinary constituents, and ultimately to build and deploy a noninvasive highthroughput biodosimeter.

Original languageEnglish (US)
Pages (from-to)503-521
Number of pages19
JournalMass Spectrometry Reviews
Volume29
Issue number3
DOIs
StatePublished - May 1 2010

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All Science Journal Classification (ASJC) codes

  • Analytical Chemistry
  • Condensed Matter Physics
  • Biochemistry, Genetics and Molecular Biology(all)
  • Spectroscopy

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