The Role of MRI Biomarkers and Their Interactions with Cognitive Status and APOE ϵ4 in Nondemented Elderly Subjects

Xue Liang, Zhenyu Yin, Renyuan Liu, Hui Zhao, Sichu Wu, Jiaming Lu, Zhao Qing, Yongyue Wei, Qing Yang, Bin Zhu, Yun Xu, Bing Zhang

Research output: Contribution to journalArticle

Abstract

Purpose: (1) To investigate atrophy patterns of hippocampal subfield volume and Alzheimer's disease (AD)-signature cortical thickness in mild cognitive impairment (MCI) patients; (2) to explore the association between the neuropsychological (NP) and the brain structure in the MCI and older normal cognition group; (3) to determine whether these associations were modified by the apolipoprotein E (APOE) ϵ4 gene and cognitive status. Methods: The FreeSurfer software was used for automated segmentation of hippocampal subfields and AD-signature cortical thickness for 22 MCI patients and 23 cognitive normal controls (NC). The volume, cortical thickness, and the neuropsychological scale were compared with two-sample t tests. Linear regression models were used to determine the association between the NP and the brain structure. Results: Compared with the NC group, MCI patients showed a decreased volume of the left presubiculum, subiculum and right CA2-3 and CA4-DG (p < 0.05, FDR corrected). The volume of these regions was positively correlated with NP scores. Of note, these associations depended on the cognitive status but not on the APOE ϵ4 status. The left subiculum and presubiculum volume were positively correlated with the Montreal Cognitive Assessment (MoCA) scores only in the MCI patients. Conclusion: Atrophy of the hippocampal subfields may be a powerful biomarker for MCI in the Chinese population.

Original languageEnglish (US)
Pages (from-to)270-280
Number of pages11
JournalNeurodegenerative Diseases
DOIs
StateAccepted/In press - Jan 1 2019

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Apolipoprotein E4
Biomarkers
Parahippocampal Gyrus
Atrophy
Linear Models
Hippocampus
Alzheimer Disease
Brain
Cognition
Cognitive Dysfunction
Software
Control Groups
Population
Genes

All Science Journal Classification (ASJC) codes

  • Neurology
  • Clinical Neurology

Cite this

Liang, Xue ; Yin, Zhenyu ; Liu, Renyuan ; Zhao, Hui ; Wu, Sichu ; Lu, Jiaming ; Qing, Zhao ; Wei, Yongyue ; Yang, Qing ; Zhu, Bin ; Xu, Yun ; Zhang, Bing. / The Role of MRI Biomarkers and Their Interactions with Cognitive Status and APOE ϵ4 in Nondemented Elderly Subjects. In: Neurodegenerative Diseases. 2019 ; pp. 270-280.
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abstract = "Purpose: (1) To investigate atrophy patterns of hippocampal subfield volume and Alzheimer's disease (AD)-signature cortical thickness in mild cognitive impairment (MCI) patients; (2) to explore the association between the neuropsychological (NP) and the brain structure in the MCI and older normal cognition group; (3) to determine whether these associations were modified by the apolipoprotein E (APOE) ϵ4 gene and cognitive status. Methods: The FreeSurfer software was used for automated segmentation of hippocampal subfields and AD-signature cortical thickness for 22 MCI patients and 23 cognitive normal controls (NC). The volume, cortical thickness, and the neuropsychological scale were compared with two-sample t tests. Linear regression models were used to determine the association between the NP and the brain structure. Results: Compared with the NC group, MCI patients showed a decreased volume of the left presubiculum, subiculum and right CA2-3 and CA4-DG (p < 0.05, FDR corrected). The volume of these regions was positively correlated with NP scores. Of note, these associations depended on the cognitive status but not on the APOE ϵ4 status. The left subiculum and presubiculum volume were positively correlated with the Montreal Cognitive Assessment (MoCA) scores only in the MCI patients. Conclusion: Atrophy of the hippocampal subfields may be a powerful biomarker for MCI in the Chinese population.",
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The Role of MRI Biomarkers and Their Interactions with Cognitive Status and APOE ϵ4 in Nondemented Elderly Subjects. / Liang, Xue; Yin, Zhenyu; Liu, Renyuan; Zhao, Hui; Wu, Sichu; Lu, Jiaming; Qing, Zhao; Wei, Yongyue; Yang, Qing; Zhu, Bin; Xu, Yun; Zhang, Bing.

In: Neurodegenerative Diseases, 01.01.2019, p. 270-280.

Research output: Contribution to journalArticle

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AU - Liang, Xue

AU - Yin, Zhenyu

AU - Liu, Renyuan

AU - Zhao, Hui

AU - Wu, Sichu

AU - Lu, Jiaming

AU - Qing, Zhao

AU - Wei, Yongyue

AU - Yang, Qing

AU - Zhu, Bin

AU - Xu, Yun

AU - Zhang, Bing

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N2 - Purpose: (1) To investigate atrophy patterns of hippocampal subfield volume and Alzheimer's disease (AD)-signature cortical thickness in mild cognitive impairment (MCI) patients; (2) to explore the association between the neuropsychological (NP) and the brain structure in the MCI and older normal cognition group; (3) to determine whether these associations were modified by the apolipoprotein E (APOE) ϵ4 gene and cognitive status. Methods: The FreeSurfer software was used for automated segmentation of hippocampal subfields and AD-signature cortical thickness for 22 MCI patients and 23 cognitive normal controls (NC). The volume, cortical thickness, and the neuropsychological scale were compared with two-sample t tests. Linear regression models were used to determine the association between the NP and the brain structure. Results: Compared with the NC group, MCI patients showed a decreased volume of the left presubiculum, subiculum and right CA2-3 and CA4-DG (p < 0.05, FDR corrected). The volume of these regions was positively correlated with NP scores. Of note, these associations depended on the cognitive status but not on the APOE ϵ4 status. The left subiculum and presubiculum volume were positively correlated with the Montreal Cognitive Assessment (MoCA) scores only in the MCI patients. Conclusion: Atrophy of the hippocampal subfields may be a powerful biomarker for MCI in the Chinese population.

AB - Purpose: (1) To investigate atrophy patterns of hippocampal subfield volume and Alzheimer's disease (AD)-signature cortical thickness in mild cognitive impairment (MCI) patients; (2) to explore the association between the neuropsychological (NP) and the brain structure in the MCI and older normal cognition group; (3) to determine whether these associations were modified by the apolipoprotein E (APOE) ϵ4 gene and cognitive status. Methods: The FreeSurfer software was used for automated segmentation of hippocampal subfields and AD-signature cortical thickness for 22 MCI patients and 23 cognitive normal controls (NC). The volume, cortical thickness, and the neuropsychological scale were compared with two-sample t tests. Linear regression models were used to determine the association between the NP and the brain structure. Results: Compared with the NC group, MCI patients showed a decreased volume of the left presubiculum, subiculum and right CA2-3 and CA4-DG (p < 0.05, FDR corrected). The volume of these regions was positively correlated with NP scores. Of note, these associations depended on the cognitive status but not on the APOE ϵ4 status. The left subiculum and presubiculum volume were positively correlated with the Montreal Cognitive Assessment (MoCA) scores only in the MCI patients. Conclusion: Atrophy of the hippocampal subfields may be a powerful biomarker for MCI in the Chinese population.

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