The role of multiple negative social relationships in inflammatory cytokine responses to a laboratory stressor

Sunmi Song, Jennifer E. Graham-Engeland, Elizabeth J. Corwin, Rachel M. Ceballos, Shelley E. Taylor, Teresa Seeman, Laura Cousino Klein

Research output: Contribution to journalArticlepeer-review

4 Scopus citations

Abstract

The present study examined the unique impact of perceived negativity in multiple social relationships on endocrine and inflammatory responses to a laboratory stressor. Via hierarchical cluster analysis, those who reported negative social exchanges across relationships with a romantic partner, family, and their closest friend had higher mean IL-6 across time and a greater increase in TNF-α from 15 min to 75 min post stress. Those who reported negative social exchanges across relationships with roommates, family, and their closest friend showed greater IL-6 responses to stress. Differences in mean IL-6 were accounted for by either depressed mood or hostility, whereas differences in the cytokine stress responses remained significant after controlling for those factors. Overall, this research provides preliminary evidence to suggest that having multiple negative relationships may exacerbate acute inflammatory responses to a laboratory stressor independent of hostility and depressed mood.

Original languageEnglish (US)
Article numbere959
JournalPeerJ
Volume2015
Issue number6
DOIs
StatePublished - 2015

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)

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