Ten patients had serial evaluations of plasma prostaglandin E2, prostaglandin 2α, and 6-keto-PG1α during administration of cis-platinum chemotherapy. No significant changes were noted in PGF2α and 6-keto-PGF1α whereas PGE2 showed a decrease. This would indicate that the nausea and vomiting of platinum therapy is not a result of tumor release of prostaglandins. All patients had known residual cancer and all had elevated levels of PGE2 and 6-keto-PGF1α.
All Science Journal Classification (ASJC) codes
- Obstetrics and Gynecology