The role of prostaglandins in the excessive nausea and vomiting after intravascular cis-platinum therapy

Stephen L. Curry; Judith Rine; Charles W. Whitney; William A. Nahhas; Rodrique Mortel; Lawrence M. Demers

doi:10.1016/0090-8258(81)90099-8

The role of prostaglandins in the excessive nausea and vomiting after intravascular cis-platinum therapy

Stephen L. Curry, Judith Rine, Charles W. Whitney, William A. Nahhas, Rodrique Mortel, Lawrence M. Demers

Department of Pathology and Laboratory Medicine

Research output: Contribution to journal › Review article › peer-review

19 Scopus citations

Abstract

Ten patients had serial evaluations of plasma prostaglandin E₂, prostaglandin _2α, and 6-keto-PG_1α during administration of cis-platinum chemotherapy. No significant changes were noted in PGF_2α and 6-keto-PGF_1α whereas PGE₂ showed a decrease. This would indicate that the nausea and vomiting of platinum therapy is not a result of tumor release of prostaglandins. All patients had known residual cancer and all had elevated levels of PGE₂ and 6-keto-PGF_1α.

Original language	English (US)
Pages (from-to)	89-91
Number of pages	3
Journal	Gynecologic Oncology
Volume	12
Issue number	1
DOIs	https://doi.org/10.1016/0090-8258(81)90099-8
State	Published - Aug 1981

All Science Journal Classification (ASJC) codes

Oncology
Obstetrics and Gynecology

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10.1016/0090-8258(81)90099-8

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title = "The role of prostaglandins in the excessive nausea and vomiting after intravascular cis-platinum therapy",

abstract = "Ten patients had serial evaluations of plasma prostaglandin E2, prostaglandin 2α, and 6-keto-PG1α during administration of cis-platinum chemotherapy. No significant changes were noted in PGF2α and 6-keto-PGF1α whereas PGE2 showed a decrease. This would indicate that the nausea and vomiting of platinum therapy is not a result of tumor release of prostaglandins. All patients had known residual cancer and all had elevated levels of PGE2 and 6-keto-PGF1α.",

author = "Curry, {Stephen L.} and Judith Rine and Whitney, {Charles W.} and Nahhas, {William A.} and Rodrique Mortel and Demers, {Lawrence M.}",

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AU - Curry, Stephen L.

AU - Rine, Judith

AU - Whitney, Charles W.

AU - Nahhas, William A.

AU - Mortel, Rodrique

AU - Demers, Lawrence M.

PY - 1981/8

Y1 - 1981/8

N2 - Ten patients had serial evaluations of plasma prostaglandin E2, prostaglandin 2α, and 6-keto-PG1α during administration of cis-platinum chemotherapy. No significant changes were noted in PGF2α and 6-keto-PGF1α whereas PGE2 showed a decrease. This would indicate that the nausea and vomiting of platinum therapy is not a result of tumor release of prostaglandins. All patients had known residual cancer and all had elevated levels of PGE2 and 6-keto-PGF1α.

AB - Ten patients had serial evaluations of plasma prostaglandin E2, prostaglandin 2α, and 6-keto-PG1α during administration of cis-platinum chemotherapy. No significant changes were noted in PGF2α and 6-keto-PGF1α whereas PGE2 showed a decrease. This would indicate that the nausea and vomiting of platinum therapy is not a result of tumor release of prostaglandins. All patients had known residual cancer and all had elevated levels of PGE2 and 6-keto-PGF1α.

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JO - Gynecologic Oncology

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The role of prostaglandins in the excessive nausea and vomiting after intravascular cis-platinum therapy

Abstract

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