The role of radiation therapy in the management of sialorrhea

A systematic review

Nathan M. Hawkey, Nicholas Zaorsky, Thomas J. Galloway

Research output: Contribution to journalReview article

12 Citations (Scopus)

Abstract

Purpose Up to 80% of patients with Parkinson disease and 30% of patients with amyotrophic lateral sclerosis (ALS) suffer from sialorrhea. Patients who fail medical and surgical therapy should be considered for external beam radiation therapy (EBRT). In this study, we conduct a systematic review to determine the dose and techniques used that result in greatest efficacy and lowest toxicity for the administration of EBRT in patients with Parkinson disease or ALS-associated sialorrhea. Methods and Materials This review included 216 patients from four prospective and six retrospective studies published from 1998 to 2014, with ALS or Parkinson disease who were treated with electron or photon EBRT for sialorrhea. Results A total of 216 patients were treated with EBRT from 10 studies. The indication for EBRT was failure of alternative medical treatment in all ALS patients. For patients with Parkinson disease, EBRT was the primary mode of treatment in 68% of cases. Overall, 176 (81%) of 216 patients treated with EBRT for sialorrhea reported symptomatic improvement from baseline. The most common target was the inferior two-thirds of the bilateral parotid glands and the entire bilateral submandibular glands. The total number of patients who experienced short-term toxicity was 86 of 216 patients (40%). The total number of patients who experienced long-term toxicity was 24 of 207 (12%). Conclusions EBRT is an effective treatment for sialorrhea in patients suffering from ALS or Parkinson disease. Treatment to the bilateral submandibular glands and caudal parotid glands is the most common field arrangement.

Original languageEnglish (US)
Pages (from-to)80-85
Number of pages6
JournalLaryngoscope
Volume126
Issue number1
DOIs
StatePublished - Jan 1 2016

Fingerprint

Sialorrhea
Radiotherapy
Amyotrophic Lateral Sclerosis
Parkinson Disease
Submandibular Gland
Parotid Gland
Therapeutics
Photons

All Science Journal Classification (ASJC) codes

  • Otorhinolaryngology
  • Medicine(all)

Cite this

Hawkey, Nathan M. ; Zaorsky, Nicholas ; Galloway, Thomas J. / The role of radiation therapy in the management of sialorrhea : A systematic review. In: Laryngoscope. 2016 ; Vol. 126, No. 1. pp. 80-85.
@article{26a150a0a23b40d29a8a2e4372c9d0b9,
title = "The role of radiation therapy in the management of sialorrhea: A systematic review",
abstract = "Purpose Up to 80{\%} of patients with Parkinson disease and 30{\%} of patients with amyotrophic lateral sclerosis (ALS) suffer from sialorrhea. Patients who fail medical and surgical therapy should be considered for external beam radiation therapy (EBRT). In this study, we conduct a systematic review to determine the dose and techniques used that result in greatest efficacy and lowest toxicity for the administration of EBRT in patients with Parkinson disease or ALS-associated sialorrhea. Methods and Materials This review included 216 patients from four prospective and six retrospective studies published from 1998 to 2014, with ALS or Parkinson disease who were treated with electron or photon EBRT for sialorrhea. Results A total of 216 patients were treated with EBRT from 10 studies. The indication for EBRT was failure of alternative medical treatment in all ALS patients. For patients with Parkinson disease, EBRT was the primary mode of treatment in 68{\%} of cases. Overall, 176 (81{\%}) of 216 patients treated with EBRT for sialorrhea reported symptomatic improvement from baseline. The most common target was the inferior two-thirds of the bilateral parotid glands and the entire bilateral submandibular glands. The total number of patients who experienced short-term toxicity was 86 of 216 patients (40{\%}). The total number of patients who experienced long-term toxicity was 24 of 207 (12{\%}). Conclusions EBRT is an effective treatment for sialorrhea in patients suffering from ALS or Parkinson disease. Treatment to the bilateral submandibular glands and caudal parotid glands is the most common field arrangement.",
author = "Hawkey, {Nathan M.} and Nicholas Zaorsky and Galloway, {Thomas J.}",
year = "2016",
month = "1",
day = "1",
doi = "10.1002/lary.25444",
language = "English (US)",
volume = "126",
pages = "80--85",
journal = "Laryngoscope",
issn = "0023-852X",
publisher = "John Wiley and Sons Inc.",
number = "1",

}

The role of radiation therapy in the management of sialorrhea : A systematic review. / Hawkey, Nathan M.; Zaorsky, Nicholas; Galloway, Thomas J.

In: Laryngoscope, Vol. 126, No. 1, 01.01.2016, p. 80-85.

Research output: Contribution to journalReview article

TY - JOUR

T1 - The role of radiation therapy in the management of sialorrhea

T2 - A systematic review

AU - Hawkey, Nathan M.

AU - Zaorsky, Nicholas

AU - Galloway, Thomas J.

PY - 2016/1/1

Y1 - 2016/1/1

N2 - Purpose Up to 80% of patients with Parkinson disease and 30% of patients with amyotrophic lateral sclerosis (ALS) suffer from sialorrhea. Patients who fail medical and surgical therapy should be considered for external beam radiation therapy (EBRT). In this study, we conduct a systematic review to determine the dose and techniques used that result in greatest efficacy and lowest toxicity for the administration of EBRT in patients with Parkinson disease or ALS-associated sialorrhea. Methods and Materials This review included 216 patients from four prospective and six retrospective studies published from 1998 to 2014, with ALS or Parkinson disease who were treated with electron or photon EBRT for sialorrhea. Results A total of 216 patients were treated with EBRT from 10 studies. The indication for EBRT was failure of alternative medical treatment in all ALS patients. For patients with Parkinson disease, EBRT was the primary mode of treatment in 68% of cases. Overall, 176 (81%) of 216 patients treated with EBRT for sialorrhea reported symptomatic improvement from baseline. The most common target was the inferior two-thirds of the bilateral parotid glands and the entire bilateral submandibular glands. The total number of patients who experienced short-term toxicity was 86 of 216 patients (40%). The total number of patients who experienced long-term toxicity was 24 of 207 (12%). Conclusions EBRT is an effective treatment for sialorrhea in patients suffering from ALS or Parkinson disease. Treatment to the bilateral submandibular glands and caudal parotid glands is the most common field arrangement.

AB - Purpose Up to 80% of patients with Parkinson disease and 30% of patients with amyotrophic lateral sclerosis (ALS) suffer from sialorrhea. Patients who fail medical and surgical therapy should be considered for external beam radiation therapy (EBRT). In this study, we conduct a systematic review to determine the dose and techniques used that result in greatest efficacy and lowest toxicity for the administration of EBRT in patients with Parkinson disease or ALS-associated sialorrhea. Methods and Materials This review included 216 patients from four prospective and six retrospective studies published from 1998 to 2014, with ALS or Parkinson disease who were treated with electron or photon EBRT for sialorrhea. Results A total of 216 patients were treated with EBRT from 10 studies. The indication for EBRT was failure of alternative medical treatment in all ALS patients. For patients with Parkinson disease, EBRT was the primary mode of treatment in 68% of cases. Overall, 176 (81%) of 216 patients treated with EBRT for sialorrhea reported symptomatic improvement from baseline. The most common target was the inferior two-thirds of the bilateral parotid glands and the entire bilateral submandibular glands. The total number of patients who experienced short-term toxicity was 86 of 216 patients (40%). The total number of patients who experienced long-term toxicity was 24 of 207 (12%). Conclusions EBRT is an effective treatment for sialorrhea in patients suffering from ALS or Parkinson disease. Treatment to the bilateral submandibular glands and caudal parotid glands is the most common field arrangement.

UR - http://www.scopus.com/inward/record.url?scp=84955214906&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84955214906&partnerID=8YFLogxK

U2 - 10.1002/lary.25444

DO - 10.1002/lary.25444

M3 - Review article

VL - 126

SP - 80

EP - 85

JO - Laryngoscope

JF - Laryngoscope

SN - 0023-852X

IS - 1

ER -