The role of store-operated calcium channel in chronic inflammation

Shengyu Yang, Wei Chiao Chang

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Citation (Scopus)

Abstract

Calcium is an important second arymessenger that regulates a variety of physiological functions, including cell proliferation, enzyme metabolism, gene expression and apoptosis. In non-excitable cells such as T lymphocytes, hepatocytes, mast cells, endothelia and cancer cells, the predominant mechanism for calcium(Ca2+) entry is through store-operated Ca2+ channels (SOCs),which are activated by the emptying of intracellular Ca2+ stores. Here, we review some of the proposed gating mechanisms of store-operated Ca2+ channel and the functional implications of SOCs in the regulation of pro-inflammatory signals and tumor progression.

Original languageEnglish (US)
Title of host publicationChronic Inflammation
Subtitle of host publicationCauses, Treatment Options and Role in Disease
PublisherNova Science Publishers, Inc.
Pages1-18
Number of pages18
ISBN (Print)9781628080940
StatePublished - Dec 1 2013

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Calcium Channels
Inflammation
Calcium
Mast Cells
Endothelium
Hepatocytes
Neoplasms
Cell Proliferation
Apoptosis
T-Lymphocytes
Gene Expression
Enzymes

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Cite this

Yang, S., & Chang, W. C. (2013). The role of store-operated calcium channel in chronic inflammation. In Chronic Inflammation: Causes, Treatment Options and Role in Disease (pp. 1-18). Nova Science Publishers, Inc..
Yang, Shengyu ; Chang, Wei Chiao. / The role of store-operated calcium channel in chronic inflammation. Chronic Inflammation: Causes, Treatment Options and Role in Disease. Nova Science Publishers, Inc., 2013. pp. 1-18
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Yang, S & Chang, WC 2013, The role of store-operated calcium channel in chronic inflammation. in Chronic Inflammation: Causes, Treatment Options and Role in Disease. Nova Science Publishers, Inc., pp. 1-18.

The role of store-operated calcium channel in chronic inflammation. / Yang, Shengyu; Chang, Wei Chiao.

Chronic Inflammation: Causes, Treatment Options and Role in Disease. Nova Science Publishers, Inc., 2013. p. 1-18.

Research output: Chapter in Book/Report/Conference proceedingChapter

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Yang S, Chang WC. The role of store-operated calcium channel in chronic inflammation. In Chronic Inflammation: Causes, Treatment Options and Role in Disease. Nova Science Publishers, Inc. 2013. p. 1-18