The role of store-operated calcium channel in chronic inflammation

Shengyu Yang, Wei Chiao Chang

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations

Abstract

Calcium is an important second arymessenger that regulates a variety of physiological functions, including cell proliferation, enzyme metabolism, gene expression and apoptosis. In non-excitable cells such as T lymphocytes, hepatocytes, mast cells, endothelia and cancer cells, the predominant mechanism for calcium(Ca2+) entry is through store-operated Ca2+ channels (SOCs),which are activated by the emptying of intracellular Ca2+ stores. Here, we review some of the proposed gating mechanisms of store-operated Ca2+ channel and the functional implications of SOCs in the regulation of pro-inflammatory signals and tumor progression.

Original languageEnglish (US)
Title of host publicationChronic Inflammation
Subtitle of host publicationCauses, Treatment Options and Role in Disease
PublisherNova Science Publishers, Inc.
Pages1-18
Number of pages18
ISBN (Print)9781628080940
StatePublished - Dec 1 2013

All Science Journal Classification (ASJC) codes

  • Medicine(all)

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    Yang, S., & Chang, W. C. (2013). The role of store-operated calcium channel in chronic inflammation. In Chronic Inflammation: Causes, Treatment Options and Role in Disease (pp. 1-18). Nova Science Publishers, Inc..