The role of the neu oncogene product in cell transformation and normal development.

Y. Kokai, T. Wada, J. N. Myers, V. I. Brown, K. Dobashi, J. Cohen, J. Hamuro, D. B. Weiner, M. I. Greene

Research output: Contribution to journalReview articlepeer-review

1 Scopus citations

Abstract

p185neu, the protein product of the neu gene, is a tyrosine kinase receptor with structural similarity to the epidermal growth factor (EGF) receptor. The cognate ligand for the p185neu receptor remains unknown. We have defined: 1) stage and tissue-specific expression patterns of the neu gene product in developing tissues; 2) p185neu phosphorylation and the regulation of p185neu tyrosine kinase activity by EGF. 3) Synergistic interactions of cellular rat p185neu and EGF receptor leading to cell transformation; 4) structural and functional differences of normal and oncogenic p185neu. These observations explain some features of how p185neu is involved in normal development and neoplastic transformation.

Original languageEnglish (US)
Pages (from-to)45-57
Number of pages13
JournalPrincess Takamatsu symposia
Volume19
StatePublished - 1988

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