The role of tryptophan in neutral fructose diphosphatase

S. J. Benkovic, W. A. Frey, C. B. Libby, J. J. Villafranca

Research output: Contribution to journalArticlepeer-review

15 Scopus citations


Neutral rabbit liver fructose-1,6-diphosphatase which does not contain tryptophan has been isolated and shown to possess catalytic properties identical to that for the neutral enzyme which contains tryptophan. Criteria include pH activity optimum, EDTA and oleate activation, AMP inhibition and specific activity. However, the enzyme lacking tryptophan responds differently to proteolysis by subtilisin exhibiting a more rapid loss of sensitivity to AMP inhibition.

Original languageEnglish (US)
Pages (from-to)196-203
Number of pages8
JournalBiochemical and Biophysical Research Communications
Issue number1
StatePublished - Mar 15 1974

All Science Journal Classification (ASJC) codes

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology


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