The role of UVR and Vitamin D on T cells and inflammatory bowel disease

Stephanie Bora, Margherita T. Cantorna

Research output: Contribution to journalArticle

10 Scopus citations

Abstract

Vitamin D deficiency is associated with the development of inflammatory bowel disease (IBD). In experimental IBD the targets of vitamin D that result in protection from IBD include gut epithelial cells, innate immune cells, T cells, and the microbiota. Ultraviolet radiation (UVR) induces production of vitamin D in the skin and suppresses T cell responses in the host. There is limited data demonstrating an effect of UVR on experimental IBD but the mechanisms of UVR suppression in IBD have not been defined. There are several shared effects of vitamin D and UVR on T cells including inhibition of proliferation and suppression of IFN-γ and IL-17 producing T cells. Conversely UVR decreases and vitamin D increases IL-4 production from T cells. Together the data suggest that UVR suppression of T cells and potentially IBD are both vitamin D dependent and independent.

Original languageEnglish (US)
Pages (from-to)347-353
Number of pages7
JournalPhotochemical and Photobiological Sciences
Volume16
Issue number3
DOIs
StatePublished - Jan 1 2017

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All Science Journal Classification (ASJC) codes

  • Physical and Theoretical Chemistry

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