The serotonin transporter gene and startle response during nicotine deprivation

Jennifer A. Minnix, Jason D. Robinson, Cho Y. Lam, Brian L. Carter, Jennifer E. Foreman, David John Vandenbergh, Gail E. Tomlinson, David W. Wetter, Paul M. Cinciripini

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Affective startle probe methodology was used to examine the effects of nicotine administration and deprivation on emotional processes among individuals carrying at least one s allele versus those with the l/l genotype of the 5-Hydroxytryptamine (Serotonin) Transporter Linked Polymorphic Region, 5-HTTLPR in the promoter region of the serotonin transporter gene [solute ligand carrier family 6 member A4 (SLC6A4) or SERT]. Smokers (n=84) completed four laboratory sessions crossing deprivation (12-h deprived vs. non-deprived) with nicotine spray (nicotine vs. placebo). Participants viewed affective pictures (positive, negative, neutral) while acoustic startle probes were administered. We found that smokers with the l/l genotype showed significantly greater suppression of the startle response when provided with nicotine vs. placebo than those with the s/s or s/l genotypes. The results suggest that l/l smokers, who may have higher levels of the serotonin transporter and more rapid synaptic serotonin clearance, experience substantial reduction in activation of the defensive system when exposed to nicotine.

Original languageEnglish (US)
Pages (from-to)1-8
Number of pages8
JournalBiological Psychology
Volume86
Issue number1
DOIs
StatePublished - Jan 1 2011

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Startle Reflex
Serotonin Plasma Membrane Transport Proteins
Nicotine
Genes
Genotype
Serotonin
Placebos
Acoustics
Genetic Promoter Regions
Alleles
Ligands

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)
  • Neuropsychology and Physiological Psychology

Cite this

Minnix, J. A., Robinson, J. D., Lam, C. Y., Carter, B. L., Foreman, J. E., Vandenbergh, D. J., ... Cinciripini, P. M. (2011). The serotonin transporter gene and startle response during nicotine deprivation. Biological Psychology, 86(1), 1-8. https://doi.org/10.1016/j.biopsycho.2010.09.013
Minnix, Jennifer A. ; Robinson, Jason D. ; Lam, Cho Y. ; Carter, Brian L. ; Foreman, Jennifer E. ; Vandenbergh, David John ; Tomlinson, Gail E. ; Wetter, David W. ; Cinciripini, Paul M. / The serotonin transporter gene and startle response during nicotine deprivation. In: Biological Psychology. 2011 ; Vol. 86, No. 1. pp. 1-8.
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Minnix, JA, Robinson, JD, Lam, CY, Carter, BL, Foreman, JE, Vandenbergh, DJ, Tomlinson, GE, Wetter, DW & Cinciripini, PM 2011, 'The serotonin transporter gene and startle response during nicotine deprivation', Biological Psychology, vol. 86, no. 1, pp. 1-8. https://doi.org/10.1016/j.biopsycho.2010.09.013

The serotonin transporter gene and startle response during nicotine deprivation. / Minnix, Jennifer A.; Robinson, Jason D.; Lam, Cho Y.; Carter, Brian L.; Foreman, Jennifer E.; Vandenbergh, David John; Tomlinson, Gail E.; Wetter, David W.; Cinciripini, Paul M.

In: Biological Psychology, Vol. 86, No. 1, 01.01.2011, p. 1-8.

Research output: Contribution to journalArticle

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