The serotonin transporter: Sequence variation in Macaca fascicularis and its relationship to dominance

Cassandra Miller-Butterworth, Jay R. Kaplan, M. Michael Barmada, Stephen B. Manuck, Robert E. Ferrell

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Specific genotypes of the rhesus monkey and human serotonin transporter gene (SERT) promoter region are associated with personality traits and serotonergic activity. However, the most commonly studied promoter polymorphism (5-HTTLPR) is monomorphic in many other monkey species. To date, no systematic search for alternative potentially functional polymorphisms across the remaining coding parts of the gene has been undertaken in other primate species, despite the crucial role SERT plays in modulating serotonergic tone. We investigated whether sequence variation in this gene is associated with social rank and serotonin metabolite (5-HIAA) differences in 524 cynomolgus macaques. Sequence variation and extent of linkage disequilibrium (LD) across the regulatory and coding regions were initially characterized in 92 macaques. The exons and promoter contained 28 polymorphisms, more than double that recorded for human SERT. In further contrast to humans, the macaque SERT showed no significant LD. Potentially functional polymorphisms were genotyped in all animals. No individual variants or haplotypes were significantly associated with social rank or 5-HIAA concentrations; however, certain serotonin transporter diplotypes may modulate acquisition of dominance status.

Original languageEnglish (US)
Pages (from-to)678-696
Number of pages19
JournalBehavior Genetics
Volume37
Issue number5
DOIs
StatePublished - Sep 1 2007

Fingerprint

Serotonin Plasma Membrane Transport Proteins
Macaca fascicularis
serotonin
dominance (genetics)
transporters
gene
Macaca
polymorphism
genetic polymorphism
Genes
Hydroxyindoleacetic Acid
genes
Linkage Disequilibrium
promoter regions
linkage disequilibrium
disequilibrium
Nucleic Acid Regulatory Sequences
Macaca mulatta
Genetic Promoter Regions
primate

All Science Journal Classification (ASJC) codes

  • Ecology, Evolution, Behavior and Systematics
  • Genetics
  • Genetics(clinical)

Cite this

Miller-Butterworth, Cassandra ; Kaplan, Jay R. ; Barmada, M. Michael ; Manuck, Stephen B. ; Ferrell, Robert E. / The serotonin transporter : Sequence variation in Macaca fascicularis and its relationship to dominance. In: Behavior Genetics. 2007 ; Vol. 37, No. 5. pp. 678-696.
@article{a6a9b64ee8034a75a8488aa97d218892,
title = "The serotonin transporter: Sequence variation in Macaca fascicularis and its relationship to dominance",
abstract = "Specific genotypes of the rhesus monkey and human serotonin transporter gene (SERT) promoter region are associated with personality traits and serotonergic activity. However, the most commonly studied promoter polymorphism (5-HTTLPR) is monomorphic in many other monkey species. To date, no systematic search for alternative potentially functional polymorphisms across the remaining coding parts of the gene has been undertaken in other primate species, despite the crucial role SERT plays in modulating serotonergic tone. We investigated whether sequence variation in this gene is associated with social rank and serotonin metabolite (5-HIAA) differences in 524 cynomolgus macaques. Sequence variation and extent of linkage disequilibrium (LD) across the regulatory and coding regions were initially characterized in 92 macaques. The exons and promoter contained 28 polymorphisms, more than double that recorded for human SERT. In further contrast to humans, the macaque SERT showed no significant LD. Potentially functional polymorphisms were genotyped in all animals. No individual variants or haplotypes were significantly associated with social rank or 5-HIAA concentrations; however, certain serotonin transporter diplotypes may modulate acquisition of dominance status.",
author = "Cassandra Miller-Butterworth and Kaplan, {Jay R.} and Barmada, {M. Michael} and Manuck, {Stephen B.} and Ferrell, {Robert E.}",
year = "2007",
month = "9",
day = "1",
doi = "10.1007/s10519-007-9162-3",
language = "English (US)",
volume = "37",
pages = "678--696",
journal = "Behavior Genetics",
issn = "0001-8244",
publisher = "Springer New York",
number = "5",

}

The serotonin transporter : Sequence variation in Macaca fascicularis and its relationship to dominance. / Miller-Butterworth, Cassandra; Kaplan, Jay R.; Barmada, M. Michael; Manuck, Stephen B.; Ferrell, Robert E.

In: Behavior Genetics, Vol. 37, No. 5, 01.09.2007, p. 678-696.

Research output: Contribution to journalArticle

TY - JOUR

T1 - The serotonin transporter

T2 - Sequence variation in Macaca fascicularis and its relationship to dominance

AU - Miller-Butterworth, Cassandra

AU - Kaplan, Jay R.

AU - Barmada, M. Michael

AU - Manuck, Stephen B.

AU - Ferrell, Robert E.

PY - 2007/9/1

Y1 - 2007/9/1

N2 - Specific genotypes of the rhesus monkey and human serotonin transporter gene (SERT) promoter region are associated with personality traits and serotonergic activity. However, the most commonly studied promoter polymorphism (5-HTTLPR) is monomorphic in many other monkey species. To date, no systematic search for alternative potentially functional polymorphisms across the remaining coding parts of the gene has been undertaken in other primate species, despite the crucial role SERT plays in modulating serotonergic tone. We investigated whether sequence variation in this gene is associated with social rank and serotonin metabolite (5-HIAA) differences in 524 cynomolgus macaques. Sequence variation and extent of linkage disequilibrium (LD) across the regulatory and coding regions were initially characterized in 92 macaques. The exons and promoter contained 28 polymorphisms, more than double that recorded for human SERT. In further contrast to humans, the macaque SERT showed no significant LD. Potentially functional polymorphisms were genotyped in all animals. No individual variants or haplotypes were significantly associated with social rank or 5-HIAA concentrations; however, certain serotonin transporter diplotypes may modulate acquisition of dominance status.

AB - Specific genotypes of the rhesus monkey and human serotonin transporter gene (SERT) promoter region are associated with personality traits and serotonergic activity. However, the most commonly studied promoter polymorphism (5-HTTLPR) is monomorphic in many other monkey species. To date, no systematic search for alternative potentially functional polymorphisms across the remaining coding parts of the gene has been undertaken in other primate species, despite the crucial role SERT plays in modulating serotonergic tone. We investigated whether sequence variation in this gene is associated with social rank and serotonin metabolite (5-HIAA) differences in 524 cynomolgus macaques. Sequence variation and extent of linkage disequilibrium (LD) across the regulatory and coding regions were initially characterized in 92 macaques. The exons and promoter contained 28 polymorphisms, more than double that recorded for human SERT. In further contrast to humans, the macaque SERT showed no significant LD. Potentially functional polymorphisms were genotyped in all animals. No individual variants or haplotypes were significantly associated with social rank or 5-HIAA concentrations; however, certain serotonin transporter diplotypes may modulate acquisition of dominance status.

UR - http://www.scopus.com/inward/record.url?scp=35148900967&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=35148900967&partnerID=8YFLogxK

U2 - 10.1007/s10519-007-9162-3

DO - 10.1007/s10519-007-9162-3

M3 - Article

C2 - 17605101

AN - SCOPUS:35148900967

VL - 37

SP - 678

EP - 696

JO - Behavior Genetics

JF - Behavior Genetics

SN - 0001-8244

IS - 5

ER -