The severity of excitotoxic brain injury is dependent on brain temperature in immature rat

John W. McDonald, Chu Kuang Chen, William H. Trescher, Michael V. Johnston

Research output: Contribution to journalArticle

43 Citations (Scopus)

Abstract

The effect of brain temperature on the severity of excitotoxic brain injury was evaluated in perinatal rats. Postnatal day (PND) 7 rats received unilateral intrastriatal injections of 25 nmol N-methyl-d-aspartate (NMDA) and then were exposed for 2 h to one of six different ambient temperatures. Animals were sacrificed 5 days later and the severity of brain injury was assessed quantitatively by comparison of the weights of the injected and contralateral cerebral hemispheres. Injection of NMDA consistently produced extensive unilateral brain injury in rats maintained at normothermia (36°C ambient temperature; 29 ± 1.8% reduction in the weight of the injected hemisphere). In the range of ambient temperatures between 25°C and 40°C, there was a linear relationship between temperature and the severity of NMDA-induced injury (r2 = 0.95, P < 0.001, linear regression). In a separate analysis, in PND 7 rats, a positive linear relationship between ambient temperature (28°C and 40°C) and brain temperature was observed (r2 = 0.96, P < 0.001). These data suggest that the severity of excitotoxic brain injury is dependent upon brain temperature.

Original languageEnglish (US)
Pages (from-to)83-86
Number of pages4
JournalNeuroscience letters
Volume126
Issue number1
DOIs
StatePublished - May 13 1991

Fingerprint

Brain Injuries
Temperature
Brain
Aspartic Acid
Injections
Cerebrum
Weight Loss
Linear Models
Weights and Measures
Wounds and Injuries

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)

Cite this

McDonald, John W. ; Chen, Chu Kuang ; Trescher, William H. ; Johnston, Michael V. / The severity of excitotoxic brain injury is dependent on brain temperature in immature rat. In: Neuroscience letters. 1991 ; Vol. 126, No. 1. pp. 83-86.
@article{103213ee4ba847e7bc6d7f87672edbe9,
title = "The severity of excitotoxic brain injury is dependent on brain temperature in immature rat",
abstract = "The effect of brain temperature on the severity of excitotoxic brain injury was evaluated in perinatal rats. Postnatal day (PND) 7 rats received unilateral intrastriatal injections of 25 nmol N-methyl-d-aspartate (NMDA) and then were exposed for 2 h to one of six different ambient temperatures. Animals were sacrificed 5 days later and the severity of brain injury was assessed quantitatively by comparison of the weights of the injected and contralateral cerebral hemispheres. Injection of NMDA consistently produced extensive unilateral brain injury in rats maintained at normothermia (36°C ambient temperature; 29 ± 1.8{\%} reduction in the weight of the injected hemisphere). In the range of ambient temperatures between 25°C and 40°C, there was a linear relationship between temperature and the severity of NMDA-induced injury (r2 = 0.95, P < 0.001, linear regression). In a separate analysis, in PND 7 rats, a positive linear relationship between ambient temperature (28°C and 40°C) and brain temperature was observed (r2 = 0.96, P < 0.001). These data suggest that the severity of excitotoxic brain injury is dependent upon brain temperature.",
author = "McDonald, {John W.} and Chen, {Chu Kuang} and Trescher, {William H.} and Johnston, {Michael V.}",
year = "1991",
month = "5",
day = "13",
doi = "10.1016/0304-3940(91)90377-6",
language = "English (US)",
volume = "126",
pages = "83--86",
journal = "Neuroscience Letters",
issn = "0304-3940",
publisher = "Elsevier Ireland Ltd",
number = "1",

}

The severity of excitotoxic brain injury is dependent on brain temperature in immature rat. / McDonald, John W.; Chen, Chu Kuang; Trescher, William H.; Johnston, Michael V.

In: Neuroscience letters, Vol. 126, No. 1, 13.05.1991, p. 83-86.

Research output: Contribution to journalArticle

TY - JOUR

T1 - The severity of excitotoxic brain injury is dependent on brain temperature in immature rat

AU - McDonald, John W.

AU - Chen, Chu Kuang

AU - Trescher, William H.

AU - Johnston, Michael V.

PY - 1991/5/13

Y1 - 1991/5/13

N2 - The effect of brain temperature on the severity of excitotoxic brain injury was evaluated in perinatal rats. Postnatal day (PND) 7 rats received unilateral intrastriatal injections of 25 nmol N-methyl-d-aspartate (NMDA) and then were exposed for 2 h to one of six different ambient temperatures. Animals were sacrificed 5 days later and the severity of brain injury was assessed quantitatively by comparison of the weights of the injected and contralateral cerebral hemispheres. Injection of NMDA consistently produced extensive unilateral brain injury in rats maintained at normothermia (36°C ambient temperature; 29 ± 1.8% reduction in the weight of the injected hemisphere). In the range of ambient temperatures between 25°C and 40°C, there was a linear relationship between temperature and the severity of NMDA-induced injury (r2 = 0.95, P < 0.001, linear regression). In a separate analysis, in PND 7 rats, a positive linear relationship between ambient temperature (28°C and 40°C) and brain temperature was observed (r2 = 0.96, P < 0.001). These data suggest that the severity of excitotoxic brain injury is dependent upon brain temperature.

AB - The effect of brain temperature on the severity of excitotoxic brain injury was evaluated in perinatal rats. Postnatal day (PND) 7 rats received unilateral intrastriatal injections of 25 nmol N-methyl-d-aspartate (NMDA) and then were exposed for 2 h to one of six different ambient temperatures. Animals were sacrificed 5 days later and the severity of brain injury was assessed quantitatively by comparison of the weights of the injected and contralateral cerebral hemispheres. Injection of NMDA consistently produced extensive unilateral brain injury in rats maintained at normothermia (36°C ambient temperature; 29 ± 1.8% reduction in the weight of the injected hemisphere). In the range of ambient temperatures between 25°C and 40°C, there was a linear relationship between temperature and the severity of NMDA-induced injury (r2 = 0.95, P < 0.001, linear regression). In a separate analysis, in PND 7 rats, a positive linear relationship between ambient temperature (28°C and 40°C) and brain temperature was observed (r2 = 0.96, P < 0.001). These data suggest that the severity of excitotoxic brain injury is dependent upon brain temperature.

UR - http://www.scopus.com/inward/record.url?scp=0025817237&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0025817237&partnerID=8YFLogxK

U2 - 10.1016/0304-3940(91)90377-6

DO - 10.1016/0304-3940(91)90377-6

M3 - Article

C2 - 1866088

AN - SCOPUS:0025817237

VL - 126

SP - 83

EP - 86

JO - Neuroscience Letters

JF - Neuroscience Letters

SN - 0304-3940

IS - 1

ER -