The skin, a novel niche for recirculating B cells

Skye A. Geherin, Sarah R. Fintushel, Michael H. Lee, R. Paul Wilson, Reema T. Patel, Carsten Alt, Alan J. Young, John B. Hay, Gudrun F. Debes

Research output: Contribution to journalArticle

44 Scopus citations

Abstract

B cells infiltrate the skin in many chronic inflammatory diseases caused by autoimmunity or infection. Despite potential contribution to disease, skin-associated B cells remain poorly characterized. Using an ovine model of granulomatous skin inflammation, we demonstrate that B cells increase in the skin and skin-draining afferent lymph during inflammation. Surprisingly, skin B cells are a heterogeneous population that is distinct from lymph node B cells, with more large lymphocytes as well as B-1-like B cells that coexpress high levels of IgM and CD11b. Skin B cells have increased MHC class II, CD1, and CD80/86 expression compared with lymph node B cells, suggesting that they are well-suited for T cell activation at the site of inflammation. Furthermore, we show that skin accumulation of B cells and Ab-secreting cells during inflammation increases local Ab titers, which could augment host defense and autoimmunity. Although skin B cells express typical skin-homing receptors, such as E-selectin ligand and α-4 and β-1 integrins, they are unresponsive to ligands for chemokine receptors associated with T cell homing into skin. Instead, skin B cells migrate toward the cutaneously expressed CCR6 ligand CCL20. Our data support a model in which B cells use CCR6- CCL20 to recirculate through the skin, fulfilling a novel role in skin immunity and inflammation.

Original languageEnglish (US)
Pages (from-to)6027-6035
Number of pages9
JournalJournal of Immunology
Volume188
Issue number12
DOIs
StatePublished - Jun 15 2012

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Immunology

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  • Cite this

    Geherin, S. A., Fintushel, S. R., Lee, M. H., Wilson, R. P., Patel, R. T., Alt, C., Young, A. J., Hay, J. B., & Debes, G. F. (2012). The skin, a novel niche for recirculating B cells. Journal of Immunology, 188(12), 6027-6035. https://doi.org/10.4049/jimmunol.1102639