The HLA‐Bw4 and Bw6 antigenic determinants have been shown to co‐migrate with HLA‐B determinants on gel‐filtration, sucrose density gradient centrifugation and affinity chromatography, using Lens culinaris lectin and antibody against human β2 microbulin. These and other published data imply that the HLA‐Bw4 and Bw6 determinants reside on the same polypeptide chain as other HLA‐B locus determinants. The implications of this in terms of the evolution of cross reacting groups of antigens at the HLA‐B locus are discussed.
|Original language||English (US)|
|Number of pages||8|
|State||Published - May 1979|
All Science Journal Classification (ASJC) codes
- Immunology and Allergy