The Structure and Evolution of the HLA‐Bw4 and Bw6 Antigens

Colin J. Barnstable, David Snary, Michael J. Crumpton, Walter F. Bodmer

Research output: Contribution to journalArticlepeer-review

23 Scopus citations

Abstract

The HLA‐Bw4 and Bw6 antigenic determinants have been shown to co‐migrate with HLA‐B determinants on gel‐filtration, sucrose density gradient centrifugation and affinity chromatography, using Lens culinaris lectin and antibody against human β2 microbulin. These and other published data imply that the HLA‐Bw4 and Bw6 determinants reside on the same polypeptide chain as other HLA‐B locus determinants. The implications of this in terms of the evolution of cross reacting groups of antigens at the HLA‐B locus are discussed.

Original languageEnglish (US)
Pages (from-to)334-341
Number of pages8
JournalTissue Antigens
Volume13
Issue number5
DOIs
StatePublished - May 1979

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Immunology
  • Biochemistry
  • Genetics

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