The success of pharmacogenomics in moving genetic association studies from bench to bedside: Study design and implementation of precision medicine in the post-GWAS era

Marylyn Deriggi Ritchie

Research output: Contribution to journalReview article

48 Citations (Scopus)

Abstract

Pharmacogenomics is emerging as a popular type of study for human genetics in recent years. This is primarily due to the many success stories and high potential for translation to clinical practice. In this review, the strengths and limitations of pharmacogenomics are discussed as well as the primary epidemiologic, clinical trial, and in vitro study designs implemented. A brief discussion of molecular and analytic approaches will be reviewed. Finally, several examples of bench-to-bedside clinical implementations of pharmacogenetic traits will be described. Pharmacogenomics continues to grow in popularity because of the important genetic associations identified that drive the possibility of precision medicine.

Original languageEnglish (US)
Pages (from-to)1615-1626
Number of pages12
JournalHuman genetics
Volume131
Issue number10
DOIs
StatePublished - Jan 1 2012

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Precision Medicine
Genome-Wide Association Study
Pharmacogenetics
Genetic Association Studies
Medical Genetics
Clinical Trials

All Science Journal Classification (ASJC) codes

  • Genetics
  • Genetics(clinical)

Cite this

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The success of pharmacogenomics in moving genetic association studies from bench to bedside : Study design and implementation of precision medicine in the post-GWAS era. / Ritchie, Marylyn Deriggi.

In: Human genetics, Vol. 131, No. 10, 01.01.2012, p. 1615-1626.

Research output: Contribution to journalReview article

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