The synthesis of carboxylic acids with carboxyl carbons of precisely known stable isotopic composition

Erwin A. Vogler, J. M. Hayes

Research output: Contribution to journalArticle

10 Scopus citations

Abstract

A procedure is described which allows the preparation of carboxylic acids in which the carbon isotopic composition of the carboxyl carbon atom is known to within better than 0.002% 13C (95% confidence limits). In this procedure, a Grignard reagent is first reacted with CO2 of known isotopic composition. After hydrolysis of the salt of the carboxylic acid, the unreacted CO2 is recovered and the isotopic composition determined. The isotopic composition of the carboxyl carbon is then calculated by difference. A differential error analysis in which all relevant uncertainties are considered is presented. Approximate kinetic isotope effect values for carboxylation of a Grignard reagent at -78°C can be determined from the observed isotopic fractionations, with five observations yielding 12k/13k = 1.059(σ = 0.009).

Original languageEnglish (US)
Pages (from-to)297-300
Number of pages4
JournalThe International Journal Of Applied Radiation And Isotopes
Volume29
Issue number4-5
DOIs
StatePublished - Jan 1 1978

All Science Journal Classification (ASJC) codes

  • Radiation
  • Nuclear Energy and Engineering
  • Radiology Nuclear Medicine and imaging

Fingerprint Dive into the research topics of 'The synthesis of carboxylic acids with carboxyl carbons of precisely known stable isotopic composition'. Together they form a unique fingerprint.

  • Cite this