The Tec family of tyrosine kinases in T cells, amplifiers of T cell receptor signals

Avery August, Angela Fischer, Shengli Hao, Cynthia Mueller, Melanie Ragin

Research output: Contribution to journalShort survey

23 Scopus citations

Abstract

ITK and Rlk/Txk are the predominant Tec family of tyrosine kinases expressed in T cells, and are involved in T cell antigen receptor mediated activation of T cells. These kinases require prior activation of Lck, Zap-70 and PI3-kinase for efficient activation. They share major substrates with both Lck and Zap-70, however the pathways they regulate are unclear. Recent evidence suggests that these kinases may not activate unique pathways, but instead serve as amplifiers for the upstream kinases Lck and Zap-70. This review will discuss the evidence for this view.

Original languageEnglish (US)
Pages (from-to)1184-1189
Number of pages6
JournalInternational Journal of Biochemistry and Cell Biology
Volume34
Issue number10
DOIs
StatePublished - Jan 1 2002

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Cell Biology

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