The Temporal Relationship in Arterial and Venous Prostacyclin and Thromboxane Activity during 24 Hours of Intraaortic Balloon Counterpulsation in Dogs

Eddie L. Hoover, Bassam Kharma, Margery Ross, Hueldine Webb, Hwei Kang Hsu, Luther Clark, Bruce Toporoff, Joseph N. Cunningham

Research output: Contribution to journalArticle

3 Scopus citations

Abstract

We studied the effects of intraaortic balloon counterpulsation (IABCP) on prostacyclin (PGI2) and thromboxane (TXB2) levels in dogs during 24 hours of 1:1 IABCP or a sham procedure in which the balloon was positioned but left deflated. The arterial PGI2 levels in the IABCP group increased from control values of 95 ± 20 pg/ml to 268 ± 95 pg/ml at 1 hour, 429 ± 95 pg/ml at 4 hours, and 1,884 ± 532 pg/ml at 24 hours. The arterial PGI2 levels were consistently higher in the IABCP group. Although the TXB2 measurements revealed no significant differences between groups, the IABCP group consistently had a higher level than the sham group. The platelet count in the control group decreased to 45% of baseline levels versus 55% for the IABCP group. We conclude that prolonged IABCP results in either net production of PGI2 or decreased degradation. The correlation between TXB2 and platelet counts is unclear and remains to be defined.

Original languageEnglish (US)
Pages (from-to)661-665
Number of pages5
JournalAnnals of Thoracic Surgery
Volume46
Issue number6
DOIs
Publication statusPublished - Jan 1 1988

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All Science Journal Classification (ASJC) codes

  • Surgery
  • Pulmonary and Respiratory Medicine
  • Cardiology and Cardiovascular Medicine

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