The traditional and a new version of the mouse H-2 complex

Jan Klein, Antonio Juretí, Constantin N. Baxevanis, Zoltan A. Nagy

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Abstract

The H-2 complex has traditionally been interpreted as a maze of regions, subregions and loci coding for different traits. The two main theses presented here are, first, that a single H-2 locus is pleiomorphic in that it controls several functions such as allograft rejection, cell-mediated lymphocytotoxicity, mixed lymphocyte reaction, immune response, immune suppression and restriction of T-cell specificity; and second, that the physiological f unction of the H-2 complex is to guide T lymphocytes in theirfunction of distinguishing self from non-self, and that all other H-2-controlled traits are artificial derivatives of this basic function. These two theses lead to a new, simplified interpretation of the H-2 complex.

Original languageEnglish (US)
Pages (from-to)455-460
Number of pages6
JournalNature
Volume291
Issue number5815
DOIs
Publication statusPublished - Jan 1 1981

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All Science Journal Classification (ASJC) codes

  • General

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Klein, J., Juretí, A., Baxevanis, C. N., & Nagy, Z. A. (1981). The traditional and a new version of the mouse H-2 complex. Nature, 291(5815), 455-460. https://doi.org/10.1038/291455a0