The ubiquitin-specific protease 14 (USP14) is a critical regulator of long-term memory formation

Timothy J. Jarome, Janine L. Kwapis, Jada J. Hallengren, Scott M. Wilson, Fred J. Helmstetter

Research output: Contribution to journalArticlepeer-review

30 Scopus citations

Abstract

Numerous studies have suggested a role for ubiquitin-proteasome-mediated protein degradation in learning-dependent synaptic plasticity; however, very little is known about how protein degradation is regulated at the level of the proteasome during memory formation. The ubiquitin-specific protease 14 (USP14) is a proteasomal deubiquitinating enzyme that is thought to regulate protein degradation in neurons; however, it is unknown if USP14 is involved in learning-dependent synaptic plasticity. We found that infusion of a USP14 inhibitor into the amygdala impaired long-term memory for a fear conditioning task, suggesting that USP14 is a critical regulator of long-term memory formation in the amygdala.

Original languageEnglish (US)
Pages (from-to)9-13
Number of pages5
JournalLearning and Memory
Volume21
Issue number1
DOIs
StatePublished - Jan 2014

All Science Journal Classification (ASJC) codes

  • Neuropsychology and Physiological Psychology
  • Cognitive Neuroscience
  • Cellular and Molecular Neuroscience

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