The unique chemistry of benzoxaboroles: Current and emerging applications in biotechnology and therapeutic treatments

C. Tony Liu, John W. Tomsho, Stephen Benkovic

Research output: Contribution to journalReview article

57 Citations (Scopus)

Abstract

Benzoxaboroles have garnered much attention in recent years due to their diverse applications in bio-sensing technology, material science, and therapeutic intervention. Part of the reason arises from the benzoxaboroles' unique chemical properties, especially in comparison to their acyclic boronic acid counterparts. Furthermore, the low bio-toxicity combined with the high target specificity associated with benzoxaboroles make them very attractive as therapeutic agents. Herein, we provide an updated summary on the current knowledge of the fundamental chemical reactivity of benzoxaboroles, followed by highlighting their major applications reported to date.

Original languageEnglish (US)
Pages (from-to)4462-4473
Number of pages12
JournalBioorganic and Medicinal Chemistry
Volume22
Issue number16
DOIs
StatePublished - Aug 15 2014

Fingerprint

Biotechnology
Acyclic Acids
Boronic Acids
Chemical reactivity
Materials science
Chemical properties
Toxicity
Technology
Therapeutics

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

Cite this

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abstract = "Benzoxaboroles have garnered much attention in recent years due to their diverse applications in bio-sensing technology, material science, and therapeutic intervention. Part of the reason arises from the benzoxaboroles' unique chemical properties, especially in comparison to their acyclic boronic acid counterparts. Furthermore, the low bio-toxicity combined with the high target specificity associated with benzoxaboroles make them very attractive as therapeutic agents. Herein, we provide an updated summary on the current knowledge of the fundamental chemical reactivity of benzoxaboroles, followed by highlighting their major applications reported to date.",
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The unique chemistry of benzoxaboroles : Current and emerging applications in biotechnology and therapeutic treatments. / Liu, C. Tony; Tomsho, John W.; Benkovic, Stephen.

In: Bioorganic and Medicinal Chemistry, Vol. 22, No. 16, 15.08.2014, p. 4462-4473.

Research output: Contribution to journalReview article

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