The use of exogenous surfactant in three pediatric patients following gastric aspiration

N. J. Thomas, S. A. Webb, J. Smith, F. W. Tecklenburg, D. M. Habib

Research output: Contribution to journalArticle

Abstract

Mortality due to ARDS of all etiologies is at least 50%. However, mortality due to ARDS induced by pulmonary aspiration of gastric contents is reportedly greater than 90%. We report the cases of 3 children who aspirated gastric contents and who were subsequently treated with intratracheal surfactant in the hope of reversing the pulmonary dysfunction-hypoxemia and low compliance-associated with their ARDS. All 3 patients demonstrated improvement in oxygenation and compliance after the first dose of surfactant and 2 survived without apparent pulmonary morbidity; 1 patient did not survive but did show transient improvement. Well-controlled clinical trials are needed to expose the therapeutic benefit of surfactant therapy in ARDS from aspiration of gastric contents.

Original languageEnglish (US)
Pages (from-to)912-916
Number of pages5
JournalRespiratory care
Volume39
Issue number9
StatePublished - Jan 1 1994

All Science Journal Classification (ASJC) codes

  • Pulmonary and Respiratory Medicine
  • Critical Care and Intensive Care Medicine

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    Thomas, N. J., Webb, S. A., Smith, J., Tecklenburg, F. W., & Habib, D. M. (1994). The use of exogenous surfactant in three pediatric patients following gastric aspiration. Respiratory care, 39(9), 912-916.