The use of nanoparticulates to treat breast cancer

Xiaomeng Tang; Welley S. Loc; Cheng Dong; Gail L. Matters; Peter J. Butler; Mark Kester; Craig Meyers; Yixing Jiang; James H. Adair

doi:10.2217/nnm-2017-0202

The use of nanoparticulates to treat breast cancer

Xiaomeng Tang, Welley S. Loc, Cheng Dong, Gail L. Matters, Peter J. Butler, Mark Kester, Craig Meyers, Yixing Jiang, James H. Adair

Research output: Contribution to journal › Review article › peer-review

65 Scopus citations

Abstract

Breast cancer is a major ongoing public health issue among women in both developing and developed countries. Significant progress has been made to improve the breast cancer treatment in the past decades. However, the current clinical approaches are invasive, of low specificity and can generate severe side effects. As a rapidly developing field, nanotechnology brings promising opportunities to human cancer diagnosis and treatment. The use of nanoparticulate-based platforms overcomes biological barriers and allows prolonged blood circulation time, simultaneous tumor targeting and enhanced accumulation of drugs in tumors. Currently available and clinically applicable innovative nanoparticulate-based systems for breast cancer nanotherapies are discussed in this review.

Original language	English (US)
Pages (from-to)	2367-2388
Number of pages	22
Journal	Nanomedicine
Volume	12
Issue number	19
DOIs	https://doi.org/10.2217/nnm-2017-0202
State	Published - Oct 2017

All Science Journal Classification (ASJC) codes

Bioengineering
Medicine (miscellaneous)
Biomedical Engineering
Materials Science(all)

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.2217/nnm-2017-0202

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title = "The use of nanoparticulates to treat breast cancer",

abstract = "Breast cancer is a major ongoing public health issue among women in both developing and developed countries. Significant progress has been made to improve the breast cancer treatment in the past decades. However, the current clinical approaches are invasive, of low specificity and can generate severe side effects. As a rapidly developing field, nanotechnology brings promising opportunities to human cancer diagnosis and treatment. The use of nanoparticulate-based platforms overcomes biological barriers and allows prolonged blood circulation time, simultaneous tumor targeting and enhanced accumulation of drugs in tumors. Currently available and clinically applicable innovative nanoparticulate-based systems for breast cancer nanotherapies are discussed in this review.",

author = "Xiaomeng Tang and Loc, {Welley S.} and Cheng Dong and Matters, {Gail L.} and Butler, {Peter J.} and Mark Kester and Craig Meyers and Yixing Jiang and Adair, {James H.}",

note = "Funding Information: This?review?was?funded?partially?by?NIH?grants?R01CA167535? and?R21CA170121?from?the?National?Cancer?Institute?(NCI)? for?the?CPSNP?work.?The?project?was?also?supported?in?part? under?a?grant?with?the?Pennsylvania?Department?of?Health? Publisher Copyright: {\textcopyright} 2017 Future Medicine Ltd.",

year = "2017",

month = oct,

doi = "10.2217/nnm-2017-0202",

language = "English (US)",

volume = "12",

pages = "2367--2388",

journal = "Nanomedicine",

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T1 - The use of nanoparticulates to treat breast cancer

AU - Tang, Xiaomeng

AU - Loc, Welley S.

AU - Dong, Cheng

AU - Matters, Gail L.

AU - Butler, Peter J.

AU - Kester, Mark

AU - Meyers, Craig

AU - Jiang, Yixing

AU - Adair, James H.

N1 - Funding Information: This?review?was?funded?partially?by?NIH?grants?R01CA167535? and?R21CA170121?from?the?National?Cancer?Institute?(NCI)? for?the?CPSNP?work.?The?project?was?also?supported?in?part? under?a?grant?with?the?Pennsylvania?Department?of?Health? Publisher Copyright: © 2017 Future Medicine Ltd.

PY - 2017/10

Y1 - 2017/10

N2 - Breast cancer is a major ongoing public health issue among women in both developing and developed countries. Significant progress has been made to improve the breast cancer treatment in the past decades. However, the current clinical approaches are invasive, of low specificity and can generate severe side effects. As a rapidly developing field, nanotechnology brings promising opportunities to human cancer diagnosis and treatment. The use of nanoparticulate-based platforms overcomes biological barriers and allows prolonged blood circulation time, simultaneous tumor targeting and enhanced accumulation of drugs in tumors. Currently available and clinically applicable innovative nanoparticulate-based systems for breast cancer nanotherapies are discussed in this review.

AB - Breast cancer is a major ongoing public health issue among women in both developing and developed countries. Significant progress has been made to improve the breast cancer treatment in the past decades. However, the current clinical approaches are invasive, of low specificity and can generate severe side effects. As a rapidly developing field, nanotechnology brings promising opportunities to human cancer diagnosis and treatment. The use of nanoparticulate-based platforms overcomes biological barriers and allows prolonged blood circulation time, simultaneous tumor targeting and enhanced accumulation of drugs in tumors. Currently available and clinically applicable innovative nanoparticulate-based systems for breast cancer nanotherapies are discussed in this review.

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EP - 2388

JO - Nanomedicine

JF - Nanomedicine

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ER -

The use of nanoparticulates to treat breast cancer

Abstract

All Science Journal Classification (ASJC) codes

UN SDGs

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