Abstract

Breast cancer is a major ongoing public health issue among women in both developing and developed countries. Significant progress has been made to improve the breast cancer treatment in the past decades. However, the current clinical approaches are invasive, of low specificity and can generate severe side effects. As a rapidly developing field, nanotechnology brings promising opportunities to human cancer diagnosis and treatment. The use of nanoparticulate-based platforms overcomes biological barriers and allows prolonged blood circulation time, simultaneous tumor targeting and enhanced accumulation of drugs in tumors. Currently available and clinically applicable innovative nanoparticulate-based systems for breast cancer nanotherapies are discussed in this review.

Original languageEnglish (US)
Pages (from-to)2367-2388
Number of pages22
JournalNanomedicine
Volume12
Issue number19
DOIs
StatePublished - Oct 1 2017

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Tumors
Breast Neoplasms
Oncology
Hemodynamics
Blood Circulation Time
Public health
Nanotechnology
Neoplasms
Developed Countries
Developing Countries
Public Health
Pharmaceutical Preparations
Therapeutics

All Science Journal Classification (ASJC) codes

  • Bioengineering
  • Medicine (miscellaneous)
  • Biomedical Engineering
  • Materials Science(all)

Cite this

Tang, Xiaomeng ; Loc, Welley S. ; Dong, Cheng ; Matters, Gail ; Butler, Peter J. ; Kester, Mark ; Meyers, Craig ; Jiang, Yixing ; Adair, James Hansell. / The use of nanoparticulates to treat breast cancer. In: Nanomedicine. 2017 ; Vol. 12, No. 19. pp. 2367-2388.
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author = "Xiaomeng Tang and Loc, {Welley S.} and Cheng Dong and Gail Matters and Butler, {Peter J.} and Mark Kester and Craig Meyers and Yixing Jiang and Adair, {James Hansell}",
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The use of nanoparticulates to treat breast cancer. / Tang, Xiaomeng; Loc, Welley S.; Dong, Cheng; Matters, Gail; Butler, Peter J.; Kester, Mark; Meyers, Craig; Jiang, Yixing; Adair, James Hansell.

In: Nanomedicine, Vol. 12, No. 19, 01.10.2017, p. 2367-2388.

Research output: Contribution to journalReview article

TY - JOUR

T1 - The use of nanoparticulates to treat breast cancer

AU - Tang, Xiaomeng

AU - Loc, Welley S.

AU - Dong, Cheng

AU - Matters, Gail

AU - Butler, Peter J.

AU - Kester, Mark

AU - Meyers, Craig

AU - Jiang, Yixing

AU - Adair, James Hansell

PY - 2017/10/1

Y1 - 2017/10/1

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AB - Breast cancer is a major ongoing public health issue among women in both developing and developed countries. Significant progress has been made to improve the breast cancer treatment in the past decades. However, the current clinical approaches are invasive, of low specificity and can generate severe side effects. As a rapidly developing field, nanotechnology brings promising opportunities to human cancer diagnosis and treatment. The use of nanoparticulate-based platforms overcomes biological barriers and allows prolonged blood circulation time, simultaneous tumor targeting and enhanced accumulation of drugs in tumors. Currently available and clinically applicable innovative nanoparticulate-based systems for breast cancer nanotherapies are discussed in this review.

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