The UTX gene escapes X inactivation in mice and humans

Andy Greenfield, Laura Carrel, David Pennisi, Christophe Philippe, Nandita Quaderi, Pamela Siggers, Kirsten Steiner, Patrick P.L. Tam, Anthony P. Monaco, Huntington F. Willard, Peter Koopman

Research output: Contribution to journalArticle

149 Scopus citations

Abstract

We recently have identified a ubiquitously transcribed mouse Y chromosome gene, Ufy, which encodes a tetratricopeptide repeat (TPR) protein. A peptide derived from the UTY protein confers H-Y antigenicity on male cells. Here we report the characterization of a widely transcribed X-linked homologue of Uty, called Utx, which maps to the proximal region of the mouse X chromosome and which detects a human X-linked homologue at Xp11.2. Given that Uty is ubiquitously transcribed, we assayed for Utx expression from the inactive X chromosome (Xi) in mice and found that Utx escapes X chromosome inactivation. Only Smcx and the pseudoautosomal Sts gene on the mouse X chromosome have been reported previously to escape inactivation. The human UTX gene was also found to be expressed from Xi. We discuss the significance of these data for our understanding of dosage compensation of X-Y homologous genes in humans and mice.

Original languageEnglish (US)
Pages (from-to)737-742
Number of pages6
JournalHuman molecular genetics
Volume7
Issue number4
DOIs
StatePublished - Apr 1 1998

All Science Journal Classification (ASJC) codes

  • Molecular Biology
  • Genetics
  • Genetics(clinical)

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    Greenfield, A., Carrel, L., Pennisi, D., Philippe, C., Quaderi, N., Siggers, P., Steiner, K., Tam, P. P. L., Monaco, A. P., Willard, H. F., & Koopman, P. (1998). The UTX gene escapes X inactivation in mice and humans. Human molecular genetics, 7(4), 737-742. https://doi.org/10.1093/hmg/7.4.737