The wide utility of rabbits as models of human diseases

Pedro J. Esteves, Joana Abrantes, Hanna Mari Baldauf, Lbachir BenMohamed, Yuxing Chen, Neil Christensen, Javier González-Gallego, Lorenzo Giacani, Jiafen Hu, Gilla Kaplan, Oliver T. Keppler, Katherine L. Knight, Xiang Peng Kong, Dennis K. Lanning, Jacques Le Pendu, Ana Lemos De Matos, Jia Liu, Shuying Liu, Ana M. Lopes, Shan LuSheila Lukehart, Yukari C. Manabe, Fabiana Neves, Grant McFadden, Ruimin Pan, Xuwen Peng, Patricia de Sousa-Pereira, Ana Pinheiro, Masmudur Rahman, Natalie Ruvoën-Clouet, Selvakumar Subbian, Maria Jesús Tuñón, Wessel van der Loo, Michael Vaine, Laura E. Via, Shixia Wang, Rose Mage

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Studies using the European rabbit Oryctolagus cuniculus contributed to elucidating numerous fundamental aspects of antibody structure and diversification mechanisms and continue to be valuable for the development and testing of therapeutic humanized polyclonal and monoclonal antibodies. Additionally, during the last two decades, the use of the European rabbit as an animal model has been increasingly extended to many human diseases. This review documents the continuing wide utility of the rabbit as a reliable disease model for development of therapeutics and vaccines and studies of the cellular and molecular mechanisms underlying many human diseases. Examples include syphilis, tuberculosis, HIV-AIDS, acute hepatic failure and diseases caused by noroviruses, ocular herpes, and papillomaviruses. The use of rabbits for vaccine development studies, which began with Louis Pasteur’s rabies vaccine in 1881, continues today with targets that include the potentially blinding HSV-1 virus infection and HIV-AIDS. Additionally, two highly fatal viral diseases, rabbit hemorrhagic disease and myxomatosis, affect the European rabbit and provide unique models to understand co-evolution between a vertebrate host and viral pathogens.

Original languageEnglish (US)
Article number66
JournalExperimental and Molecular Medicine
Volume50
Issue number5
DOIs
StatePublished - May 2018

Fingerprint

Rabbits
Virus Diseases
Vaccines
Acquired Immunodeficiency Syndrome
Rabies Vaccines
HIV
Antibodies, Monoclonal, Humanized
Norovirus
Pathogens
Acute Liver Failure
Viruses
Human Herpesvirus 1
Syphilis
Animals
Vertebrates
Monoclonal Antibodies
Tuberculosis
Animal Models
Antibodies
Testing

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Clinical Biochemistry

Cite this

Esteves, P. J., Abrantes, J., Baldauf, H. M., BenMohamed, L., Chen, Y., Christensen, N., ... Mage, R. (2018). The wide utility of rabbits as models of human diseases. Experimental and Molecular Medicine, 50(5), [66]. https://doi.org/10.1038/s12276-018-0094-1
Esteves, Pedro J. ; Abrantes, Joana ; Baldauf, Hanna Mari ; BenMohamed, Lbachir ; Chen, Yuxing ; Christensen, Neil ; González-Gallego, Javier ; Giacani, Lorenzo ; Hu, Jiafen ; Kaplan, Gilla ; Keppler, Oliver T. ; Knight, Katherine L. ; Kong, Xiang Peng ; Lanning, Dennis K. ; Le Pendu, Jacques ; De Matos, Ana Lemos ; Liu, Jia ; Liu, Shuying ; Lopes, Ana M. ; Lu, Shan ; Lukehart, Sheila ; Manabe, Yukari C. ; Neves, Fabiana ; McFadden, Grant ; Pan, Ruimin ; Peng, Xuwen ; de Sousa-Pereira, Patricia ; Pinheiro, Ana ; Rahman, Masmudur ; Ruvoën-Clouet, Natalie ; Subbian, Selvakumar ; Tuñón, Maria Jesús ; van der Loo, Wessel ; Vaine, Michael ; Via, Laura E. ; Wang, Shixia ; Mage, Rose. / The wide utility of rabbits as models of human diseases. In: Experimental and Molecular Medicine. 2018 ; Vol. 50, No. 5.
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Esteves, PJ, Abrantes, J, Baldauf, HM, BenMohamed, L, Chen, Y, Christensen, N, González-Gallego, J, Giacani, L, Hu, J, Kaplan, G, Keppler, OT, Knight, KL, Kong, XP, Lanning, DK, Le Pendu, J, De Matos, AL, Liu, J, Liu, S, Lopes, AM, Lu, S, Lukehart, S, Manabe, YC, Neves, F, McFadden, G, Pan, R, Peng, X, de Sousa-Pereira, P, Pinheiro, A, Rahman, M, Ruvoën-Clouet, N, Subbian, S, Tuñón, MJ, van der Loo, W, Vaine, M, Via, LE, Wang, S & Mage, R 2018, 'The wide utility of rabbits as models of human diseases', Experimental and Molecular Medicine, vol. 50, no. 5, 66. https://doi.org/10.1038/s12276-018-0094-1

The wide utility of rabbits as models of human diseases. / Esteves, Pedro J.; Abrantes, Joana; Baldauf, Hanna Mari; BenMohamed, Lbachir; Chen, Yuxing; Christensen, Neil; González-Gallego, Javier; Giacani, Lorenzo; Hu, Jiafen; Kaplan, Gilla; Keppler, Oliver T.; Knight, Katherine L.; Kong, Xiang Peng; Lanning, Dennis K.; Le Pendu, Jacques; De Matos, Ana Lemos; Liu, Jia; Liu, Shuying; Lopes, Ana M.; Lu, Shan; Lukehart, Sheila; Manabe, Yukari C.; Neves, Fabiana; McFadden, Grant; Pan, Ruimin; Peng, Xuwen; de Sousa-Pereira, Patricia; Pinheiro, Ana; Rahman, Masmudur; Ruvoën-Clouet, Natalie; Subbian, Selvakumar; Tuñón, Maria Jesús; van der Loo, Wessel; Vaine, Michael; Via, Laura E.; Wang, Shixia; Mage, Rose.

In: Experimental and Molecular Medicine, Vol. 50, No. 5, 66, 05.2018.

Research output: Contribution to journalArticle

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T1 - The wide utility of rabbits as models of human diseases

AU - Esteves, Pedro J.

AU - Abrantes, Joana

AU - Baldauf, Hanna Mari

AU - BenMohamed, Lbachir

AU - Chen, Yuxing

AU - Christensen, Neil

AU - González-Gallego, Javier

AU - Giacani, Lorenzo

AU - Hu, Jiafen

AU - Kaplan, Gilla

AU - Keppler, Oliver T.

AU - Knight, Katherine L.

AU - Kong, Xiang Peng

AU - Lanning, Dennis K.

AU - Le Pendu, Jacques

AU - De Matos, Ana Lemos

AU - Liu, Jia

AU - Liu, Shuying

AU - Lopes, Ana M.

AU - Lu, Shan

AU - Lukehart, Sheila

AU - Manabe, Yukari C.

AU - Neves, Fabiana

AU - McFadden, Grant

AU - Pan, Ruimin

AU - Peng, Xuwen

AU - de Sousa-Pereira, Patricia

AU - Pinheiro, Ana

AU - Rahman, Masmudur

AU - Ruvoën-Clouet, Natalie

AU - Subbian, Selvakumar

AU - Tuñón, Maria Jesús

AU - van der Loo, Wessel

AU - Vaine, Michael

AU - Via, Laura E.

AU - Wang, Shixia

AU - Mage, Rose

PY - 2018/5

Y1 - 2018/5

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