The wMelPop strain of Wolbachia interferes with dopamine levels in Aedes aegypti

Luciano A. Moreira, Yixin H. Ye, Karly Turner, Darryl W. Eyles, Elizabeth A. McGraw, Scott L. O'Neill

Research output: Contribution to journalArticle

18 Scopus citations

Abstract

Wolbachia is an intracellular bacterium that has been stably transinfected into the mosquito vector of dengue, Aedes aegypti. This inherited infection causes a range of metabolic and phenotypic alterations in the mosquito, which might be related to neuronal abnormalities. In order to determine if these alterations were caused by the manipulation of neuroamines by this bacterium, we studied the expression of genes involved in the dopamine biosynthetic pathway and also measured the amount of dopamine in infected and uninfected mosquitoes of different ages. Wolbachia-infected mosquitoes exhibit greater expression of some genes related to the melanization pathway, but not for those directly linked to dopamine production. Although dopamine levels were higher in Wolbachia-positive mosquitoes this was not consistent across all insect ages nor was it related to the previously described Wolbachia induced "bendy" and "shaky" phenotypes.

Original languageEnglish (US)
Article number28
JournalParasites and Vectors
Volume4
Issue number1
DOIs
StatePublished - Mar 2 2011

All Science Journal Classification (ASJC) codes

  • Parasitology
  • Infectious Diseases

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