The Wuhan Twin Birth Cohort (WTBC)

Jinzhu Zhao, Shaoping Yang, Anna Peng, Zhengmin Qian, Hong Xian, Tianjiao Chen, Guanghui Dong, Yiming Zhang, Xijiang Hu, Zhong Chen, Jiangxia Cao, Xiaojie Song, Shunqing Xu, Tongzhang Zheng, Bin Zhang

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

The Wuhan Pre/Post-Natal Twin Birth Registry (WPTBR) is one of the largest twin birth registries with comprehensive medical information in China. It recruits women from the first trimester of pregnancy and their twins from birth. From January 2006 to May 2016, the total number of twins enrolled in WPTBR is 13,869 twin pairs (27,553 individuals). The WPTBR initiated the Wuhan Twin Birth Cohort (WTBC). The WTBC is a prospective cohort study carried out through incorporation of three samples. The first one comprises 6,920 twin pairs, and the second one, 6,949 twin pairs. Both are population-based samples linked to the WPTBR and include pre- and post-natal information from WPTBR. The second sample includes neonatal blood spots as well. Using a hospital-based approach, we recently developed a third sample with a target enrolment of 1,000 twin pairs and their mothers. These twins are invited, via their parents, to participate in a periodic health examination from the first trimester of pregnancy to 18 years. Biological samples are collected initially from the mother, including blood, urine, cord blood, cord, amniotic fluid, placenta, breast milk and meconium, and vaginal secretions, and later from the twins, including meconium, stool, urine, and blood. This article describes the design, recruitment, follow-up, data collection, and measures, as well as ongoing and planned analyses at the WTBC. The WTBC offers a unique opportunity to follow women from prenatal to postnatal, as well as follow-up of their twins. This cohort study will expand the understanding of genetic and environmental influences on pregnancy and twins' development in China.

Original languageEnglish (US)
Pages (from-to)355-362
Number of pages8
JournalTwin Research and Human Genetics
Volume20
Issue number4
DOIs
StatePublished - Aug 1 2017

Fingerprint

Parturition
Registries
Meconium
First Pregnancy Trimester
China
Cohort Studies
Mothers
Urine
Twin Pregnancy
Human Milk
Amniotic Fluid
Fetal Blood
Placenta
Parents
Prospective Studies

All Science Journal Classification (ASJC) codes

  • Pediatrics, Perinatology, and Child Health
  • Obstetrics and Gynecology
  • Genetics(clinical)

Cite this

Zhao, J., Yang, S., Peng, A., Qian, Z., Xian, H., Chen, T., ... Zhang, B. (2017). The Wuhan Twin Birth Cohort (WTBC). Twin Research and Human Genetics, 20(4), 355-362. https://doi.org/10.1017/thg.2017.24
Zhao, Jinzhu ; Yang, Shaoping ; Peng, Anna ; Qian, Zhengmin ; Xian, Hong ; Chen, Tianjiao ; Dong, Guanghui ; Zhang, Yiming ; Hu, Xijiang ; Chen, Zhong ; Cao, Jiangxia ; Song, Xiaojie ; Xu, Shunqing ; Zheng, Tongzhang ; Zhang, Bin. / The Wuhan Twin Birth Cohort (WTBC). In: Twin Research and Human Genetics. 2017 ; Vol. 20, No. 4. pp. 355-362.
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Zhao, J, Yang, S, Peng, A, Qian, Z, Xian, H, Chen, T, Dong, G, Zhang, Y, Hu, X, Chen, Z, Cao, J, Song, X, Xu, S, Zheng, T & Zhang, B 2017, 'The Wuhan Twin Birth Cohort (WTBC)', Twin Research and Human Genetics, vol. 20, no. 4, pp. 355-362. https://doi.org/10.1017/thg.2017.24

The Wuhan Twin Birth Cohort (WTBC). / Zhao, Jinzhu; Yang, Shaoping; Peng, Anna; Qian, Zhengmin; Xian, Hong; Chen, Tianjiao; Dong, Guanghui; Zhang, Yiming; Hu, Xijiang; Chen, Zhong; Cao, Jiangxia; Song, Xiaojie; Xu, Shunqing; Zheng, Tongzhang; Zhang, Bin.

In: Twin Research and Human Genetics, Vol. 20, No. 4, 01.08.2017, p. 355-362.

Research output: Contribution to journalArticle

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AU - Zhao, Jinzhu

AU - Yang, Shaoping

AU - Peng, Anna

AU - Qian, Zhengmin

AU - Xian, Hong

AU - Chen, Tianjiao

AU - Dong, Guanghui

AU - Zhang, Yiming

AU - Hu, Xijiang

AU - Chen, Zhong

AU - Cao, Jiangxia

AU - Song, Xiaojie

AU - Xu, Shunqing

AU - Zheng, Tongzhang

AU - Zhang, Bin

PY - 2017/8/1

Y1 - 2017/8/1

N2 - The Wuhan Pre/Post-Natal Twin Birth Registry (WPTBR) is one of the largest twin birth registries with comprehensive medical information in China. It recruits women from the first trimester of pregnancy and their twins from birth. From January 2006 to May 2016, the total number of twins enrolled in WPTBR is 13,869 twin pairs (27,553 individuals). The WPTBR initiated the Wuhan Twin Birth Cohort (WTBC). The WTBC is a prospective cohort study carried out through incorporation of three samples. The first one comprises 6,920 twin pairs, and the second one, 6,949 twin pairs. Both are population-based samples linked to the WPTBR and include pre- and post-natal information from WPTBR. The second sample includes neonatal blood spots as well. Using a hospital-based approach, we recently developed a third sample with a target enrolment of 1,000 twin pairs and their mothers. These twins are invited, via their parents, to participate in a periodic health examination from the first trimester of pregnancy to 18 years. Biological samples are collected initially from the mother, including blood, urine, cord blood, cord, amniotic fluid, placenta, breast milk and meconium, and vaginal secretions, and later from the twins, including meconium, stool, urine, and blood. This article describes the design, recruitment, follow-up, data collection, and measures, as well as ongoing and planned analyses at the WTBC. The WTBC offers a unique opportunity to follow women from prenatal to postnatal, as well as follow-up of their twins. This cohort study will expand the understanding of genetic and environmental influences on pregnancy and twins' development in China.

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Zhao J, Yang S, Peng A, Qian Z, Xian H, Chen T et al. The Wuhan Twin Birth Cohort (WTBC). Twin Research and Human Genetics. 2017 Aug 1;20(4):355-362. https://doi.org/10.1017/thg.2017.24