A theoretical framework for the study of the process of adoption of nursing information systems is presented. The theory of interactionism provides a framework within which one can begin to understand variation in reactions to a computer system. This theory states that behavior is a function of the individual in interaction with his or her environment. To understand reactions to computerization, characteristics of the individuals learning to use the system must be taken into account, as well as characteristics of the environment (which would include characteristics of the system). Characteristics of the individuals and the environment interact in complex ways to determine response to computerization. Individual and environmental characteristics of potential relevance to reactions to nursing information systems are presented. An ongoing study is described concerning nurses' reactions to a hospital information system utilizing the theoretical framework of interactionism.