Theory of Mind disruption and recruitment of the right hemisphere during narrative comprehension in autism

Robert A. Mason, Diane L. Williams, Rajesh K. Kana, Nancy Minshew, Marcel Adam Just

Research output: Contribution to journalArticlepeer-review

187 Scopus citations

Abstract

The intersection of Theory of Mind (ToM) processing and complex narrative comprehension in high functioning autism was examined by comparing cortical activation during the reading of passages that required inferences based on either intentions, emotional states, or physical causality. Right hemisphere activation was substantially greater for all sentences in the autism group than in a matched control group suggesting decreased LH capacity in autism resulting in a spillover of processing to RH homologs. Moreover, the ToM network was disrupted. The autism group showed similar activation for all inference types in the right temporo-parietal component of the ToM network whereas the control participants selectively activated this network only when appropriate. The autism group had lower functional connectivity within the ToM network and also between the ToM and a left hemisphere language network. Furthermore, the within-network functional connectivity in autism was correlated with the size of the anterior portion of the corpus callosum.

Original languageEnglish (US)
Pages (from-to)269-280
Number of pages12
JournalNeuropsychologia
Volume46
Issue number1
DOIs
StatePublished - 2008

All Science Journal Classification (ASJC) codes

  • Experimental and Cognitive Psychology
  • Cognitive Neuroscience
  • Behavioral Neuroscience

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