Theory of Mind disruption and recruitment of the right hemisphere during narrative comprehension in autism

Robert A. Mason, Diane L. Williams, Rajesh K. Kana, Nancy Minshew, Marcel Adam Just

Research output: Contribution to journalArticle

165 Citations (Scopus)

Abstract

The intersection of Theory of Mind (ToM) processing and complex narrative comprehension in high functioning autism was examined by comparing cortical activation during the reading of passages that required inferences based on either intentions, emotional states, or physical causality. Right hemisphere activation was substantially greater for all sentences in the autism group than in a matched control group suggesting decreased LH capacity in autism resulting in a spillover of processing to RH homologs. Moreover, the ToM network was disrupted. The autism group showed similar activation for all inference types in the right temporo-parietal component of the ToM network whereas the control participants selectively activated this network only when appropriate. The autism group had lower functional connectivity within the ToM network and also between the ToM and a left hemisphere language network. Furthermore, the within-network functional connectivity in autism was correlated with the size of the anterior portion of the corpus callosum.

Original languageEnglish (US)
Pages (from-to)269-280
Number of pages12
JournalNeuropsychologia
Volume46
Issue number1
DOIs
StatePublished - Jan 22 2008

Fingerprint

Theory of Mind
Autistic Disorder
Portion Size
Corpus Callosum
Causality
Reading
Research Design
Language
Control Groups

All Science Journal Classification (ASJC) codes

  • Experimental and Cognitive Psychology
  • Cognitive Neuroscience
  • Behavioral Neuroscience

Cite this

Mason, Robert A. ; Williams, Diane L. ; Kana, Rajesh K. ; Minshew, Nancy ; Just, Marcel Adam. / Theory of Mind disruption and recruitment of the right hemisphere during narrative comprehension in autism. In: Neuropsychologia. 2008 ; Vol. 46, No. 1. pp. 269-280.
@article{3add5cdf8ab14e3b9c76f3720efb17fe,
title = "Theory of Mind disruption and recruitment of the right hemisphere during narrative comprehension in autism",
abstract = "The intersection of Theory of Mind (ToM) processing and complex narrative comprehension in high functioning autism was examined by comparing cortical activation during the reading of passages that required inferences based on either intentions, emotional states, or physical causality. Right hemisphere activation was substantially greater for all sentences in the autism group than in a matched control group suggesting decreased LH capacity in autism resulting in a spillover of processing to RH homologs. Moreover, the ToM network was disrupted. The autism group showed similar activation for all inference types in the right temporo-parietal component of the ToM network whereas the control participants selectively activated this network only when appropriate. The autism group had lower functional connectivity within the ToM network and also between the ToM and a left hemisphere language network. Furthermore, the within-network functional connectivity in autism was correlated with the size of the anterior portion of the corpus callosum.",
author = "Mason, {Robert A.} and Williams, {Diane L.} and Kana, {Rajesh K.} and Nancy Minshew and Just, {Marcel Adam}",
year = "2008",
month = "1",
day = "22",
doi = "10.1016/j.neuropsychologia.2007.07.018",
language = "English (US)",
volume = "46",
pages = "269--280",
journal = "Neuropsychologia",
issn = "0028-3932",
publisher = "Elsevier Limited",
number = "1",

}

Theory of Mind disruption and recruitment of the right hemisphere during narrative comprehension in autism. / Mason, Robert A.; Williams, Diane L.; Kana, Rajesh K.; Minshew, Nancy; Just, Marcel Adam.

In: Neuropsychologia, Vol. 46, No. 1, 22.01.2008, p. 269-280.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Theory of Mind disruption and recruitment of the right hemisphere during narrative comprehension in autism

AU - Mason, Robert A.

AU - Williams, Diane L.

AU - Kana, Rajesh K.

AU - Minshew, Nancy

AU - Just, Marcel Adam

PY - 2008/1/22

Y1 - 2008/1/22

N2 - The intersection of Theory of Mind (ToM) processing and complex narrative comprehension in high functioning autism was examined by comparing cortical activation during the reading of passages that required inferences based on either intentions, emotional states, or physical causality. Right hemisphere activation was substantially greater for all sentences in the autism group than in a matched control group suggesting decreased LH capacity in autism resulting in a spillover of processing to RH homologs. Moreover, the ToM network was disrupted. The autism group showed similar activation for all inference types in the right temporo-parietal component of the ToM network whereas the control participants selectively activated this network only when appropriate. The autism group had lower functional connectivity within the ToM network and also between the ToM and a left hemisphere language network. Furthermore, the within-network functional connectivity in autism was correlated with the size of the anterior portion of the corpus callosum.

AB - The intersection of Theory of Mind (ToM) processing and complex narrative comprehension in high functioning autism was examined by comparing cortical activation during the reading of passages that required inferences based on either intentions, emotional states, or physical causality. Right hemisphere activation was substantially greater for all sentences in the autism group than in a matched control group suggesting decreased LH capacity in autism resulting in a spillover of processing to RH homologs. Moreover, the ToM network was disrupted. The autism group showed similar activation for all inference types in the right temporo-parietal component of the ToM network whereas the control participants selectively activated this network only when appropriate. The autism group had lower functional connectivity within the ToM network and also between the ToM and a left hemisphere language network. Furthermore, the within-network functional connectivity in autism was correlated with the size of the anterior portion of the corpus callosum.

UR - http://www.scopus.com/inward/record.url?scp=38149040923&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=38149040923&partnerID=8YFLogxK

U2 - 10.1016/j.neuropsychologia.2007.07.018

DO - 10.1016/j.neuropsychologia.2007.07.018

M3 - Article

VL - 46

SP - 269

EP - 280

JO - Neuropsychologia

JF - Neuropsychologia

SN - 0028-3932

IS - 1

ER -