Therapeutic interventions to disrupt the protein synthetic machinery in melanoma

Gregory R. Kardos, Gavin P. Robertson

Research output: Contribution to journalReview article

3 Citations (Scopus)

Abstract

Control of the protein synthetic machinery is deregulated in many cancers, including melanoma, to increase the protein production. Tumor suppressors and oncogenes play key roles in protein synthesis from the transcription of rRNA and ribosome biogenesis to mRNA translation initiation and protein synthesis. Major signaling pathways are altered in melanoma to modulate the protein synthetic machinery, thereby promoting tumor development. However, despite the importance of this process in melanoma development, involvement of the protein synthetic machinery in this cancer type is an underdeveloped area of study. Here, we review the coupling of melanoma development to deregulation of the protein synthetic machinery. We examine existing knowledge regarding RNA polymerase I inhibition and mRNA translation focusing on their inhibition for therapeutic applications in melanoma. Furthermore, the contribution of amino acid biosynthesis and involvement of ribosomal proteins are also reviewed as future therapeutic strategies to target deregulated protein production in melanoma.

Original languageEnglish (US)
Pages (from-to)501-519
Number of pages19
JournalPigment Cell and Melanoma Research
Volume28
Issue number5
DOIs
StatePublished - Sep 1 2015

Fingerprint

Machinery
Melanoma
Protein Biosynthesis
Proteins
Therapeutics
Tumors
Neoplasms
RNA Polymerase I
Messenger RNA
Deregulation
Ribosomal Proteins
Biosynthesis
Transcription
Ribosomes
Oncogenes
Amino Acids

All Science Journal Classification (ASJC) codes

  • Oncology
  • Biochemistry, Genetics and Molecular Biology(all)
  • Dermatology

Cite this

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abstract = "Control of the protein synthetic machinery is deregulated in many cancers, including melanoma, to increase the protein production. Tumor suppressors and oncogenes play key roles in protein synthesis from the transcription of rRNA and ribosome biogenesis to mRNA translation initiation and protein synthesis. Major signaling pathways are altered in melanoma to modulate the protein synthetic machinery, thereby promoting tumor development. However, despite the importance of this process in melanoma development, involvement of the protein synthetic machinery in this cancer type is an underdeveloped area of study. Here, we review the coupling of melanoma development to deregulation of the protein synthetic machinery. We examine existing knowledge regarding RNA polymerase I inhibition and mRNA translation focusing on their inhibition for therapeutic applications in melanoma. Furthermore, the contribution of amino acid biosynthesis and involvement of ribosomal proteins are also reviewed as future therapeutic strategies to target deregulated protein production in melanoma.",
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Therapeutic interventions to disrupt the protein synthetic machinery in melanoma. / Kardos, Gregory R.; Robertson, Gavin P.

In: Pigment Cell and Melanoma Research, Vol. 28, No. 5, 01.09.2015, p. 501-519.

Research output: Contribution to journalReview article

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