Therapy for chronic hepatitis B: The earlier, the better?

Jianming Hu, David Nguyen

Research output: Contribution to journalShort survey

7 Citations (Scopus)

Abstract

It has been recently reported that uninfected hepatocytes that repopulate the liver following clearance of a chronic hepatitis B virus infection are derived from previously infected cells. As these cells accumulate genetic damage over the course of infection, the risk of liver cancer arising from this damage might not be eliminated by viral clearance. Therefore, initiation of antiviral therapy early in the course of infection to prevent the accumulation of this damage is proposed to be the best course of action.

Original languageEnglish (US)
Pages (from-to)431-433
Number of pages3
JournalTrends in Microbiology
Volume12
Issue number10
DOIs
StatePublished - Oct 1 2004

Fingerprint

Chronic Hepatitis B
Virus Diseases
Liver Neoplasms
Infection
Hepatitis B virus
Antiviral Agents
Hepatocytes
Liver
Therapeutics

All Science Journal Classification (ASJC) codes

  • Microbiology
  • Microbiology (medical)
  • Infectious Diseases
  • Virology

Cite this

Hu, Jianming ; Nguyen, David. / Therapy for chronic hepatitis B : The earlier, the better?. In: Trends in Microbiology. 2004 ; Vol. 12, No. 10. pp. 431-433.
@article{3cd7482151ef488ca3b2ce7a944289e5,
title = "Therapy for chronic hepatitis B: The earlier, the better?",
abstract = "It has been recently reported that uninfected hepatocytes that repopulate the liver following clearance of a chronic hepatitis B virus infection are derived from previously infected cells. As these cells accumulate genetic damage over the course of infection, the risk of liver cancer arising from this damage might not be eliminated by viral clearance. Therefore, initiation of antiviral therapy early in the course of infection to prevent the accumulation of this damage is proposed to be the best course of action.",
author = "Jianming Hu and David Nguyen",
year = "2004",
month = "10",
day = "1",
doi = "10.1016/j.tim.2004.08.007",
language = "English (US)",
volume = "12",
pages = "431--433",
journal = "Trends in Microbiology",
issn = "0966-842X",
publisher = "Elsevier Limited",
number = "10",

}

Therapy for chronic hepatitis B : The earlier, the better? / Hu, Jianming; Nguyen, David.

In: Trends in Microbiology, Vol. 12, No. 10, 01.10.2004, p. 431-433.

Research output: Contribution to journalShort survey

TY - JOUR

T1 - Therapy for chronic hepatitis B

T2 - The earlier, the better?

AU - Hu, Jianming

AU - Nguyen, David

PY - 2004/10/1

Y1 - 2004/10/1

N2 - It has been recently reported that uninfected hepatocytes that repopulate the liver following clearance of a chronic hepatitis B virus infection are derived from previously infected cells. As these cells accumulate genetic damage over the course of infection, the risk of liver cancer arising from this damage might not be eliminated by viral clearance. Therefore, initiation of antiviral therapy early in the course of infection to prevent the accumulation of this damage is proposed to be the best course of action.

AB - It has been recently reported that uninfected hepatocytes that repopulate the liver following clearance of a chronic hepatitis B virus infection are derived from previously infected cells. As these cells accumulate genetic damage over the course of infection, the risk of liver cancer arising from this damage might not be eliminated by viral clearance. Therefore, initiation of antiviral therapy early in the course of infection to prevent the accumulation of this damage is proposed to be the best course of action.

UR - http://www.scopus.com/inward/record.url?scp=4644247157&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=4644247157&partnerID=8YFLogxK

U2 - 10.1016/j.tim.2004.08.007

DO - 10.1016/j.tim.2004.08.007

M3 - Short survey

C2 - 15381188

AN - SCOPUS:4644247157

VL - 12

SP - 431

EP - 433

JO - Trends in Microbiology

JF - Trends in Microbiology

SN - 0966-842X

IS - 10

ER -