Thiol-dependent lipid peroxidation

Ming Tien, John R. Bucher, Steven D. Aust

Research output: Contribution to journalArticle

129 Citations (Scopus)

Abstract

Initiation of lipid peroxidation in liposomes by cysteine, glutathione, or dithiothreitol required iron, and was not inhibited by superoxide dismutase. The absence of superoxide involvement in thiol autoxidation was confirmed by the inability of superoxide dismutase to inhibit thiol reduction of cytochrome c. Furthermore, the rate of cytochrome c reduction by thiols was not decreased under anaerobic conditions. We suggest that lipid peroxidation initiated by thiols and iron occurs via direct reduction of iron. Control of cellular thiol autoxidation, and reactions occurring as a consequence, such as lipid peroxidation, must therefore involve chelation of transition metals to control their redox reactions.

Original languageEnglish (US)
Pages (from-to)279-285
Number of pages7
JournalBiochemical and Biophysical Research Communications
Volume107
Issue number1
DOIs
StatePublished - Jul 16 1982

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Sulfhydryl Compounds
Lipid Peroxidation
Lipids
Iron
Cytochromes c
Superoxide Dismutase
Redox reactions
Dithiothreitol
Chelation
Liposomes
Superoxides
Oxidation-Reduction
Transition metals
Glutathione
Cysteine
Metals

All Science Journal Classification (ASJC) codes

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

Cite this

Tien, Ming ; Bucher, John R. ; Aust, Steven D. / Thiol-dependent lipid peroxidation. In: Biochemical and Biophysical Research Communications. 1982 ; Vol. 107, No. 1. pp. 279-285.
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Thiol-dependent lipid peroxidation. / Tien, Ming; Bucher, John R.; Aust, Steven D.

In: Biochemical and Biophysical Research Communications, Vol. 107, No. 1, 16.07.1982, p. 279-285.

Research output: Contribution to journalArticle

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