Third-Generation Optical Coherence Tomography Findings in Punctate Retinal Toxoplasmosis

Juliana L. Oréfice, Rogério A. Costa, Wesley Campos, Daniela Calucci, Ingrid Scott, Fernando Oréfice

Research output: Contribution to journalArticlepeer-review

14 Scopus citations

Abstract

Purpose: To investigate optical coherence tomography (OCT) findings in patients with punctate retinal toxoplasmosis (PRT). Design: Observational case series. Methods: Setting: Tertiary ophthalmic referral center. Study Population: Four patients with PRT consecutively evaluated between July 2004 and June 2005. Observation Procedures: Clinical examination and OCT. Main Outcome Measures: Morphologic features at baseline and changes within a 24-week follow-up interval. Results: Retinal layers were abnormally hyperreflective at the active lesion site and associated with some degree of retinal pigment epithelium-choriocapillaris/choroidal optical shadowing in all patients. The posterior hyaloid was thickened and focally detached (over the lesion). Additional findings include tractional maculopathy (n = 2) and diffuse macular edema (n = 1). During follow-up, focal choriocapillaris/choroidal relative hyperreflectivity was observed at the former lesion site, and posterior vitreous detachment progressed in all patients. Conclusions: Our findings suggest that OCT may enable identification of subtle morphologic features previously underappreciated in patients with PRT, which may provide new insights about the disease pathophysiologic mechanisms.

Original languageEnglish (US)
JournalAmerican Journal of Ophthalmology
Volume142
Issue number3
DOIs
StatePublished - Jan 1 2006

All Science Journal Classification (ASJC) codes

  • Ophthalmology

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