Three-dimensional quantitation of pediatric tumor bulk

K. D. Eggli, P. Close, P. W. Dillon, M. Umlauf, K. D. Hopper

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

In pediatric oncology, therapeutic decisions are made based on tumor response to chemotherapeutic agents. Sequential measurement of tumor bulk and its percent change on therapy must be accurately assessed. Will 3-dimensional (3-D) volumetric determination improve our ability to assess tumor response to therapy? Forty-five CT scans of pediatric patients with unresectable thoracic or abdominal neoplasia were assessed for tumor bulk by the standard "2-dimensional (2-D)" volume formula (cross-sectional areaxlength) and by 3-D volumetric analysis. Thirty-two examinations were performed in follow-up, and percent change in tumor size was calculated. The 2-D volume calculation overestimated tumor volume by more than 50% on all but two examinations when the 2-D volume was compared with the 3-D volume. In 28% of follow-up examinations, the 2-D calculation of percent change differed by more than 10% from the 3-D volume. Fifteen percent differed by over 25%. This changed the response category of one patient from "no response" to "partial response". 3-D volumetric analysis, easily performed by a trained technologist, will give more accurate assessment of the actual tumor bulk and its subsequent changes in size in response to therapy. An additional, unexpected benefit of volumetric determination and its accompanying 3-D images was their use and enthusiastic acceptance by clinicians. Pediatric oncologists and surgeons used the sequential images in conferences with parents. In the future, graphic representations of tumor response to therapy might be used in determining the best time for second-look surgery or for other therapeutic manipulations.

Original languageEnglish (US)
Pages (from-to)1-6
Number of pages6
JournalPediatric Radiology
Volume25
Issue number1
DOIs
StatePublished - Feb 1 1995

Fingerprint

Pediatrics
Neoplasms
Therapeutics
Second-Look Surgery
Aptitude
Three-Dimensional Imaging
Tumor Burden
Thorax
Parents

All Science Journal Classification (ASJC) codes

  • Pediatrics, Perinatology, and Child Health
  • Radiology Nuclear Medicine and imaging

Cite this

Eggli, K. D. ; Close, P. ; Dillon, P. W. ; Umlauf, M. ; Hopper, K. D. / Three-dimensional quantitation of pediatric tumor bulk. In: Pediatric Radiology. 1995 ; Vol. 25, No. 1. pp. 1-6.
@article{7b6649eaa0f441d9aa701c83a68cd02e,
title = "Three-dimensional quantitation of pediatric tumor bulk",
abstract = "In pediatric oncology, therapeutic decisions are made based on tumor response to chemotherapeutic agents. Sequential measurement of tumor bulk and its percent change on therapy must be accurately assessed. Will 3-dimensional (3-D) volumetric determination improve our ability to assess tumor response to therapy? Forty-five CT scans of pediatric patients with unresectable thoracic or abdominal neoplasia were assessed for tumor bulk by the standard {"}2-dimensional (2-D){"} volume formula (cross-sectional areaxlength) and by 3-D volumetric analysis. Thirty-two examinations were performed in follow-up, and percent change in tumor size was calculated. The 2-D volume calculation overestimated tumor volume by more than 50{\%} on all but two examinations when the 2-D volume was compared with the 3-D volume. In 28{\%} of follow-up examinations, the 2-D calculation of percent change differed by more than 10{\%} from the 3-D volume. Fifteen percent differed by over 25{\%}. This changed the response category of one patient from {"}no response{"} to {"}partial response{"}. 3-D volumetric analysis, easily performed by a trained technologist, will give more accurate assessment of the actual tumor bulk and its subsequent changes in size in response to therapy. An additional, unexpected benefit of volumetric determination and its accompanying 3-D images was their use and enthusiastic acceptance by clinicians. Pediatric oncologists and surgeons used the sequential images in conferences with parents. In the future, graphic representations of tumor response to therapy might be used in determining the best time for second-look surgery or for other therapeutic manipulations.",
author = "Eggli, {K. D.} and P. Close and Dillon, {P. W.} and M. Umlauf and Hopper, {K. D.}",
year = "1995",
month = "2",
day = "1",
doi = "10.1007/BF02020828",
language = "English (US)",
volume = "25",
pages = "1--6",
journal = "Pediatric Radiology",
issn = "0301-0449",
publisher = "Springer Verlag",
number = "1",

}

Eggli, KD, Close, P, Dillon, PW, Umlauf, M & Hopper, KD 1995, 'Three-dimensional quantitation of pediatric tumor bulk', Pediatric Radiology, vol. 25, no. 1, pp. 1-6. https://doi.org/10.1007/BF02020828

Three-dimensional quantitation of pediatric tumor bulk. / Eggli, K. D.; Close, P.; Dillon, P. W.; Umlauf, M.; Hopper, K. D.

In: Pediatric Radiology, Vol. 25, No. 1, 01.02.1995, p. 1-6.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Three-dimensional quantitation of pediatric tumor bulk

AU - Eggli, K. D.

AU - Close, P.

AU - Dillon, P. W.

AU - Umlauf, M.

AU - Hopper, K. D.

PY - 1995/2/1

Y1 - 1995/2/1

N2 - In pediatric oncology, therapeutic decisions are made based on tumor response to chemotherapeutic agents. Sequential measurement of tumor bulk and its percent change on therapy must be accurately assessed. Will 3-dimensional (3-D) volumetric determination improve our ability to assess tumor response to therapy? Forty-five CT scans of pediatric patients with unresectable thoracic or abdominal neoplasia were assessed for tumor bulk by the standard "2-dimensional (2-D)" volume formula (cross-sectional areaxlength) and by 3-D volumetric analysis. Thirty-two examinations were performed in follow-up, and percent change in tumor size was calculated. The 2-D volume calculation overestimated tumor volume by more than 50% on all but two examinations when the 2-D volume was compared with the 3-D volume. In 28% of follow-up examinations, the 2-D calculation of percent change differed by more than 10% from the 3-D volume. Fifteen percent differed by over 25%. This changed the response category of one patient from "no response" to "partial response". 3-D volumetric analysis, easily performed by a trained technologist, will give more accurate assessment of the actual tumor bulk and its subsequent changes in size in response to therapy. An additional, unexpected benefit of volumetric determination and its accompanying 3-D images was their use and enthusiastic acceptance by clinicians. Pediatric oncologists and surgeons used the sequential images in conferences with parents. In the future, graphic representations of tumor response to therapy might be used in determining the best time for second-look surgery or for other therapeutic manipulations.

AB - In pediatric oncology, therapeutic decisions are made based on tumor response to chemotherapeutic agents. Sequential measurement of tumor bulk and its percent change on therapy must be accurately assessed. Will 3-dimensional (3-D) volumetric determination improve our ability to assess tumor response to therapy? Forty-five CT scans of pediatric patients with unresectable thoracic or abdominal neoplasia were assessed for tumor bulk by the standard "2-dimensional (2-D)" volume formula (cross-sectional areaxlength) and by 3-D volumetric analysis. Thirty-two examinations were performed in follow-up, and percent change in tumor size was calculated. The 2-D volume calculation overestimated tumor volume by more than 50% on all but two examinations when the 2-D volume was compared with the 3-D volume. In 28% of follow-up examinations, the 2-D calculation of percent change differed by more than 10% from the 3-D volume. Fifteen percent differed by over 25%. This changed the response category of one patient from "no response" to "partial response". 3-D volumetric analysis, easily performed by a trained technologist, will give more accurate assessment of the actual tumor bulk and its subsequent changes in size in response to therapy. An additional, unexpected benefit of volumetric determination and its accompanying 3-D images was their use and enthusiastic acceptance by clinicians. Pediatric oncologists and surgeons used the sequential images in conferences with parents. In the future, graphic representations of tumor response to therapy might be used in determining the best time for second-look surgery or for other therapeutic manipulations.

UR - http://www.scopus.com/inward/record.url?scp=0028905834&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0028905834&partnerID=8YFLogxK

U2 - 10.1007/BF02020828

DO - 10.1007/BF02020828

M3 - Article

C2 - 7761150

AN - SCOPUS:0028905834

VL - 25

SP - 1

EP - 6

JO - Pediatric Radiology

JF - Pediatric Radiology

SN - 0301-0449

IS - 1

ER -