Three-dimensional topography of corticopontine projections from rat sensorimotor cortex: Comparisons with corticostriatal projections reveal diverse integrative organization

Trygve B. Leergaard, Kevin D. Alloway, Tuyet A.T. Pham, Ingeborg Bolstad, Zachary S. Hoffer, Christian Pettersen, Jan G. Bjaalie

Research output: Contribution to journalArticle

42 Citations (Scopus)

Abstract

The major cortical-subcortical re-entrant pathways through the basal ganglia and cerebellum are considered to represent anatomically segregated channels for information originating in different cortical areas. A capacity for integrating unique combinations of cortical inputs has been well documented in the basal ganglia circuits but is largely undefined in the precerebellar circuits. To compare and quantify the amount of overlap that occurs in the first link of the cortico-ponto-cerebellar pathway, a dual tracing approach was used to map the spatial relationship between projections originating from the primary somatosensory cortex (SI), the secondary somatosensory cortex (SII), and the primary motor cortex (MI). The anterograde tracers biotinylated dextran amine and Fluoro-Ruby were injected into homologous whisker representations of either SI and SII, or SI and MI. The ensuing pontine labeling patterns were analyzed using a computerized three-dimensional reconstruction approach. The results demonstrate that whisker-related projections from SI and MI are largely segregated. At some locations, the two projections are adjoining and partly overlapping. Furthermore, SI contributes significantly more corticopontine projections than MI. By comparison, projections from corresponding representations in SI and SII terminate in similar parts of the pontine nuclei and display considerable amounts of spatial overlap. Finally, comparison of corticopontine and corticostriatal projections in the same experimental animals reveals that SI-SII overlap is significantly larger in the pontine nuclei than in the neostriatum. These structural differences indicate a larger capacity for integration of information within the same sensory modality in the pontocerebellar system compared to the basal ganglia.

Original languageEnglish (US)
Pages (from-to)306-322
Number of pages17
JournalJournal of Comparative Neurology
Volume478
Issue number3
DOIs
StatePublished - Oct 18 2004

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Basal Ganglia
Vibrissae
Somatosensory Cortex
Neostriatum
Motor Cortex
Cerebellum
Sensorimotor Cortex

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)

Cite this

Leergaard, Trygve B. ; Alloway, Kevin D. ; Pham, Tuyet A.T. ; Bolstad, Ingeborg ; Hoffer, Zachary S. ; Pettersen, Christian ; Bjaalie, Jan G. / Three-dimensional topography of corticopontine projections from rat sensorimotor cortex : Comparisons with corticostriatal projections reveal diverse integrative organization. In: Journal of Comparative Neurology. 2004 ; Vol. 478, No. 3. pp. 306-322.
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Three-dimensional topography of corticopontine projections from rat sensorimotor cortex : Comparisons with corticostriatal projections reveal diverse integrative organization. / Leergaard, Trygve B.; Alloway, Kevin D.; Pham, Tuyet A.T.; Bolstad, Ingeborg; Hoffer, Zachary S.; Pettersen, Christian; Bjaalie, Jan G.

In: Journal of Comparative Neurology, Vol. 478, No. 3, 18.10.2004, p. 306-322.

Research output: Contribution to journalArticle

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T1 - Three-dimensional topography of corticopontine projections from rat sensorimotor cortex

T2 - Comparisons with corticostriatal projections reveal diverse integrative organization

AU - Leergaard, Trygve B.

AU - Alloway, Kevin D.

AU - Pham, Tuyet A.T.

AU - Bolstad, Ingeborg

AU - Hoffer, Zachary S.

AU - Pettersen, Christian

AU - Bjaalie, Jan G.

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N2 - The major cortical-subcortical re-entrant pathways through the basal ganglia and cerebellum are considered to represent anatomically segregated channels for information originating in different cortical areas. A capacity for integrating unique combinations of cortical inputs has been well documented in the basal ganglia circuits but is largely undefined in the precerebellar circuits. To compare and quantify the amount of overlap that occurs in the first link of the cortico-ponto-cerebellar pathway, a dual tracing approach was used to map the spatial relationship between projections originating from the primary somatosensory cortex (SI), the secondary somatosensory cortex (SII), and the primary motor cortex (MI). The anterograde tracers biotinylated dextran amine and Fluoro-Ruby were injected into homologous whisker representations of either SI and SII, or SI and MI. The ensuing pontine labeling patterns were analyzed using a computerized three-dimensional reconstruction approach. The results demonstrate that whisker-related projections from SI and MI are largely segregated. At some locations, the two projections are adjoining and partly overlapping. Furthermore, SI contributes significantly more corticopontine projections than MI. By comparison, projections from corresponding representations in SI and SII terminate in similar parts of the pontine nuclei and display considerable amounts of spatial overlap. Finally, comparison of corticopontine and corticostriatal projections in the same experimental animals reveals that SI-SII overlap is significantly larger in the pontine nuclei than in the neostriatum. These structural differences indicate a larger capacity for integration of information within the same sensory modality in the pontocerebellar system compared to the basal ganglia.

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