Thrombolysis enhanced by dual-frequency highintensity focused ultrasound

Sijia Guo, Dingjie Suo, Yun Jing, Xiaoning Jiang, Jonathan Frank, Weili Lin

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

It has been demonstrated that high-intensity focused ultrasound can be an efficient method to induce thrombolysis. Excessive thermal effect on neighboring tissue is however a concern. The goal of this work is to test the efficacy of dual-frequency ultrasound-induced thrombolysis, with the aim to reduce the acoustic power required to achieve the same lysis rate (mass loss of blood clots over time) as single-frequency ultrasound. In vitro clots of mouse blood were prepared and placed at the focus of two piezoelectric ultrasound transducers (center frequencies were 0.95 MHz and 1.5 MHz, respectively). 0.65 W ultrasound waves with 10% duty cycle were employed in both single- and dual-frequency ultrasound exposures. The mass losses of the clots were recorded to obtain the lysis rate after each test. It was found that dual-frequency results in more efficient thrombolysis. Cavitation bubble modeling was also conducted for both single- and dual-frequency ultrasound to explain the experimental founding.

Original languageEnglish (US)
Title of host publicationIEEE International Ultrasonics Symposium, IUS
PublisherIEEE Computer Society
Pages2173-2176
Number of pages4
ISBN (Electronic)9781479970490
DOIs
StatePublished - Oct 20 2014
Event2014 IEEE International Ultrasonics Symposium, IUS 2014 - Chicago, United States
Duration: Sep 3 2014Sep 6 2014

Publication series

NameIEEE International Ultrasonics Symposium, IUS
ISSN (Print)1948-5719
ISSN (Electronic)1948-5727

Other

Other2014 IEEE International Ultrasonics Symposium, IUS 2014
CountryUnited States
CityChicago
Period9/3/149/6/14

All Science Journal Classification (ASJC) codes

  • Acoustics and Ultrasonics

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  • Cite this

    Guo, S., Suo, D., Jing, Y., Jiang, X., Frank, J., & Lin, W. (2014). Thrombolysis enhanced by dual-frequency highintensity focused ultrasound. In IEEE International Ultrasonics Symposium, IUS (pp. 2173-2176). [6932335] (IEEE International Ultrasonics Symposium, IUS). IEEE Computer Society. https://doi.org/10.1109/ULTSYM.2014.0541