Thyroid lymphoma

A single institution's experience

Francis P. Ruggiero, Elizabeth Frauenhoffer, Brendan C. Stack

Research output: Contribution to journalArticle

50 Citations (Scopus)

Abstract

BACKGROUND: Primary lymphoma of the thyroid gland is uncommon. METHODS: The tumor registry at the Penn State Milton S. Hershey Medical Center was searched for all patients carrying a diagnosis of thyroid lymphoma. All available records for these patients were examined and information regarding patient and tumor characteristics, clinical presentation, interventions, and survival were tabulated. RESULTS: The average age of patient in our series was 67.5 years. There was a 2.7:1 female to male preponderance. Thirteen (60%) patients presented with thyroid nodule(s). Eleven (50%) presented with aerodigestive tract obstructive symptoms. Sixteen (73%) patients had no pre-existing history of thyroid disease; none had known pre-existing Hashimoto's thyroiditis. CONCLUSIONS: The typical thyroid lymphoma patient is female and elderly with painless thyroid enlargement. Compressive symptoms of the aerodigestive tract are common at presentation and may require urgent intervention. Treatment modalities (XRT, CHOP chemotherapy) and outcomes are distinct from other thyroid malignancies. EBM RATING: C

Original languageEnglish (US)
Pages (from-to)888-896
Number of pages9
JournalOtolaryngology - Head and Neck Surgery
Volume133
Issue number6
DOIs
StatePublished - Dec 1 2005

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Lymphoma
Thyroid Gland
Neoplasms
Hashimoto Disease
Thyroid Nodule
Thyroid Diseases
Registries
Drug Therapy
Survival

All Science Journal Classification (ASJC) codes

  • Surgery
  • Otorhinolaryngology

Cite this

Ruggiero, Francis P. ; Frauenhoffer, Elizabeth ; Stack, Brendan C. / Thyroid lymphoma : A single institution's experience. In: Otolaryngology - Head and Neck Surgery. 2005 ; Vol. 133, No. 6. pp. 888-896.
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Thyroid lymphoma : A single institution's experience. / Ruggiero, Francis P.; Frauenhoffer, Elizabeth; Stack, Brendan C.

In: Otolaryngology - Head and Neck Surgery, Vol. 133, No. 6, 01.12.2005, p. 888-896.

Research output: Contribution to journalArticle

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T1 - Thyroid lymphoma

T2 - A single institution's experience

AU - Ruggiero, Francis P.

AU - Frauenhoffer, Elizabeth

AU - Stack, Brendan C.

PY - 2005/12/1

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N2 - BACKGROUND: Primary lymphoma of the thyroid gland is uncommon. METHODS: The tumor registry at the Penn State Milton S. Hershey Medical Center was searched for all patients carrying a diagnosis of thyroid lymphoma. All available records for these patients were examined and information regarding patient and tumor characteristics, clinical presentation, interventions, and survival were tabulated. RESULTS: The average age of patient in our series was 67.5 years. There was a 2.7:1 female to male preponderance. Thirteen (60%) patients presented with thyroid nodule(s). Eleven (50%) presented with aerodigestive tract obstructive symptoms. Sixteen (73%) patients had no pre-existing history of thyroid disease; none had known pre-existing Hashimoto's thyroiditis. CONCLUSIONS: The typical thyroid lymphoma patient is female and elderly with painless thyroid enlargement. Compressive symptoms of the aerodigestive tract are common at presentation and may require urgent intervention. Treatment modalities (XRT, CHOP chemotherapy) and outcomes are distinct from other thyroid malignancies. EBM RATING: C

AB - BACKGROUND: Primary lymphoma of the thyroid gland is uncommon. METHODS: The tumor registry at the Penn State Milton S. Hershey Medical Center was searched for all patients carrying a diagnosis of thyroid lymphoma. All available records for these patients were examined and information regarding patient and tumor characteristics, clinical presentation, interventions, and survival were tabulated. RESULTS: The average age of patient in our series was 67.5 years. There was a 2.7:1 female to male preponderance. Thirteen (60%) patients presented with thyroid nodule(s). Eleven (50%) presented with aerodigestive tract obstructive symptoms. Sixteen (73%) patients had no pre-existing history of thyroid disease; none had known pre-existing Hashimoto's thyroiditis. CONCLUSIONS: The typical thyroid lymphoma patient is female and elderly with painless thyroid enlargement. Compressive symptoms of the aerodigestive tract are common at presentation and may require urgent intervention. Treatment modalities (XRT, CHOP chemotherapy) and outcomes are distinct from other thyroid malignancies. EBM RATING: C

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