@-tide-stabilized β-hairpins

Scott T. Phillips, Landy K. Blasdel, Paul A. Bartlett

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Abstract

(Chemical Equation Presented) As minimalist versions of β-structure, two-stranded β-hairpins are commonly employed as platforms for assessing the interactions that stabilize β-sheets in proteins. We have found that the presence of a 1,6-dihydro-3(2H)-pyridinone moiety (the "@-unit") as an amino acid replacement at the i - 1 or i + 4 positions relative to a β-turn strongly stabilizes the hairpin conformation. Hybrids of this type bridge the gap between natural β-hairpins and unnatural β-sheets because the @-unit only replaces one residue in a peptide while stabilizing the hairpin conformation to a greater extent than a normal amino acid. In this report, we describe the synthesis of a variety of @-tide-templated hairpins and the NMR and CD characterization of their conformations in both polar and nonpolar solvents.

Original languageEnglish (US)
Pages (from-to)1865-1871
Number of pages7
JournalJournal of Organic Chemistry
Volume70
Issue number5
DOIs
Publication statusPublished - Mar 4 2005

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All Science Journal Classification (ASJC) codes

  • Organic Chemistry

Cite this

Phillips, S. T., Blasdel, L. K., & Bartlett, P. A. (2005). @-tide-stabilized β-hairpins. Journal of Organic Chemistry, 70(5), 1865-1871. https://doi.org/10.1021/jo047782p