Time is (still) of the essence: Quantifying the impact of emergency meningitis vaccination response in Katsina State, Nigeria

Matthew J. Ferrari, Florence Fermon, Fabienne Nackers, Augusto Llosa, Claire Magone, Rebecca F. Grais

Research output: Contribution to journalArticlepeer-review

12 Scopus citations

Abstract

Background: In 2009, a large meningitis A epidemic affected a broad region of northern Nigeria and southern Niger, resulting in more than 75 000 cases and 4000 deaths. In collaboration with state and federal agencies, Médecins Sans Frontières (MSF) intervened with a large-scale vaccination campaign using polysaccharide vaccine. Here the authors analyze the impact (cases averted) of the vaccination response as a function of the timing and coverage achieved. Methods: Phenomenological epidemic models were fitted to replicate meningitis surveillance data from the Nigerian Ministry of Health/WHO surveillance system and from reinforced surveillance conducted by MSF in both vaccinated and unvaccinated areas using a dynamic, state-space framework to account for under-reporting of cases. Results: The overall impact of the vaccination campaigns (reduction in meningitis cases) in Katsina State, northern Nigeria, ranged from 4% to 12%. At the local level, vaccination reduced cases by as much as 50% when campaigns were conducted early in the epidemic. Conclusions: Reactive vaccination with polysaccharide vaccine during meningitis outbreaks can significantly reduce the case burden when conducted early and comprehensively. Introduction of the conjugate MenAfriVac vaccine has reduced rates of disease caused by serogroup A Neisseria meningitidis in the region. Despite this, reactive campaigns with polysaccharide vaccine remain a necessary and important tool for meningitis outbreak response.

Original languageEnglish (US)
Article numberihu062
Pages (from-to)282-290
Number of pages9
JournalInternational health
Volume6
Issue number4
DOIs
StatePublished - Dec 1 2014

All Science Journal Classification (ASJC) codes

  • Health(social science)
  • Public Health, Environmental and Occupational Health

Fingerprint Dive into the research topics of 'Time is (still) of the essence: Quantifying the impact of emergency meningitis vaccination response in Katsina State, Nigeria'. Together they form a unique fingerprint.

Cite this