Time-varying Effects of GABRG1 and Maladaptive Peer Behavior on Externalizing Behavior from Childhood to Adulthood: Testing Gene × Environment × Development Effects

Elisa M. Trucco, Songshan Yang, James J. Yang, Robert A. Zucker, Runze Li, Anne Buu

Research output: Contribution to journalArticle

Abstract

Engagement in externalizing behavior is problematic. Deviant peer affiliation increases risk for externalizing behavior. Yet, peer effects vary across individuals and may differ across genes. This study determines gene × environment × development interactions as they apply to externalizing behavior from childhood to adulthood. A sample (n = 687; 68% male, 90% White) of youth from the Michigan Longitudinal Study was assessed from ages 10 to 25. Interactions between γ-amino butyric acid type A receptor γ1 subunit (GABRG1; rs7683876, rs13120165) and maladaptive peer behavior on externalizing behavior were examined using time-varying effect modeling. The findings indicate a sequential risk gradient in the influence of maladaptive peer behavior on externalizing behavior depending on the number of G alleles during childhood through adulthood. Individuals with the GG genotype are most vulnerable to maladaptive peer influences, which results in greater externalizing behavior during late childhood through early adulthood.

Original languageEnglish (US)
JournalJournal of youth and adolescence
DOIs
StateAccepted/In press - Jan 1 2019

Fingerprint

adulthood
childhood
Genes
Gene-Environment Interaction
Butyric Acid
Risk-Taking
time
interaction
Longitudinal Studies
Alleles
Genotype
longitudinal study

All Science Journal Classification (ASJC) codes

  • Social Psychology
  • Education
  • Developmental and Educational Psychology
  • Social Sciences (miscellaneous)

Cite this

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Time-varying Effects of GABRG1 and Maladaptive Peer Behavior on Externalizing Behavior from Childhood to Adulthood : Testing Gene × Environment × Development Effects. / Trucco, Elisa M.; Yang, Songshan; Yang, James J.; Zucker, Robert A.; Li, Runze; Buu, Anne.

In: Journal of youth and adolescence, 01.01.2019.

Research output: Contribution to journalArticle

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