Tirapazamine with cisplatin in patients with advanced non-small-cell lung cancer: A phase II study

Joseph Treat, Elizabeth Johnson, Corey Langer, Chandra Belani, Brenda Haynes, Richard Greenberg, Roberto Rodriquez, Patricia Drobins, Wallace Miller, Lorraine Meehan, Ann McKeon, Jeanne Devin, Reinhard Von Roemeling, Jean Viallet

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Abstract

Purpose: A phase II study was conducted to evaluate the safety and efficacy of tirapazamine combined with cisplatin for the treatment of patients with advanced non-small-cell lung cancer (NSCLC). Patients and Methods: Forty-four patients with stage IIIB/IV NSCLC were treated with a combination of tirapazamine and cisplatin. Patients received tirapazamine 260 mg/m2 administered intravenously over 2 hours, followed 1 hour later by cisplatin 75 mg/m2 administered over an additional hour, repeated every 21 days. The duration of therapy was meant to be limited to four cycles for nonresponders and eight cycles for responders. Results: Ten of 44 patients (23%) showed a partial response. The estimated median survival for all patients was 37 weeks. Toxicities were treatable and included grade 3 nausea or vomiting (25%), fatigue (27.3%), and muscle cramps (4.5%). No dose reductions were necessary. Conclusion: The results show that tirapazamine can safely be added to cisplatin. Both the median survival and response rate observed strongly suggest that tirapazamine with cisplatin is more active than cisplatin alone.

Original languageEnglish (US)
Pages (from-to)3524-3527
Number of pages4
JournalJournal of Clinical Oncology
Volume16
Issue number11
DOIs
StatePublished - Nov 1998

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

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    Treat, J., Johnson, E., Langer, C., Belani, C., Haynes, B., Greenberg, R., Rodriquez, R., Drobins, P., Miller, W., Meehan, L., McKeon, A., Devin, J., Von Roemeling, R., & Viallet, J. (1998). Tirapazamine with cisplatin in patients with advanced non-small-cell lung cancer: A phase II study. Journal of Clinical Oncology, 16(11), 3524-3527. https://doi.org/10.1200/JCO.1998.16.11.3524