Tissue and lineage-specific variation in inactive X chromosome expression of the murine Smcx gene

Laura Carrel, Patricia A. Hunt, Huntington F. Willard

Research output: Contribution to journalArticle

48 Citations (Scopus)

Abstract

To understand how gene expression patterns are established on the inactive X chromosome during development, we have studied the murine gene Smcx, which is expressed from both the active and inactive mouse X chromosomes. In all tissues assayed, Smcx only partially escapes X inactivation, with expression levels from the inactive X allele ~ 30-65% that of the active X allele. Additionally, inactive X expression levels differed between extraembryonic and embryonic tissues and among different tissues from newborn and adult mice. Imprinted extraembryonic tissue had the lowest levels of inactive X Smcx expression, whereas the highest levels were in heart. These data suggest that the chromosomal basis of X inactivation differs among tissues, perhaps reflecting differences in the timing or regulation of inactivation in these cell lineages.

Original languageEnglish (US)
Pages (from-to)1361-1366
Number of pages6
JournalHuman Molecular Genetics
Volume5
Issue number9
DOIs
StatePublished - Sep 1 1996

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X Chromosome
X Chromosome Inactivation
Genes
Alleles
Cell Lineage
Gene Expression

All Science Journal Classification (ASJC) codes

  • Molecular Biology
  • Genetics
  • Genetics(clinical)

Cite this

Carrel, Laura ; Hunt, Patricia A. ; Willard, Huntington F. / Tissue and lineage-specific variation in inactive X chromosome expression of the murine Smcx gene. In: Human Molecular Genetics. 1996 ; Vol. 5, No. 9. pp. 1361-1366.
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Tissue and lineage-specific variation in inactive X chromosome expression of the murine Smcx gene. / Carrel, Laura; Hunt, Patricia A.; Willard, Huntington F.

In: Human Molecular Genetics, Vol. 5, No. 9, 01.09.1996, p. 1361-1366.

Research output: Contribution to journalArticle

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