Tissue and lineage-specific variation in inactive X chromosome expression of the murine Smcx gene

Laura Carrel, Patricia A. Hunt, Huntington F. Willard

Research output: Contribution to journalArticle

49 Scopus citations


To understand how gene expression patterns are established on the inactive X chromosome during development, we have studied the murine gene Smcx, which is expressed from both the active and inactive mouse X chromosomes. In all tissues assayed, Smcx only partially escapes X inactivation, with expression levels from the inactive X allele ~ 30-65% that of the active X allele. Additionally, inactive X expression levels differed between extraembryonic and embryonic tissues and among different tissues from newborn and adult mice. Imprinted extraembryonic tissue had the lowest levels of inactive X Smcx expression, whereas the highest levels were in heart. These data suggest that the chromosomal basis of X inactivation differs among tissues, perhaps reflecting differences in the timing or regulation of inactivation in these cell lineages.

Original languageEnglish (US)
Pages (from-to)1361-1366
Number of pages6
JournalHuman molecular genetics
Issue number9
StatePublished - Sep 1 1996


All Science Journal Classification (ASJC) codes

  • Molecular Biology
  • Genetics
  • Genetics(clinical)

Cite this