Tissue atomization by high intensity focused ultrasound

Julianna Simon, Oleg Sapozhnikov, Vera Khokhlova, Yak Nam Wang, Lawrence Crum, Michael Bailey

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Liquid atomization and fountain formation by focused ultrasound was first published by Wood and Loomis [1]. Since then, the cavitation-wave hypothesis emerged to explain atomization in a fountain, which states atomization arises from a combination of surface capillary waves and the collapse of cavitation bubbles. More recently, high intensity focused ultrasound (HIFU) has been shown to fractionate tissue through either pulsed-cavitation or millisecond boiling histotripsy therapies; however it is unclear how millimeter-size boiling bubbles or cavitation bubble clouds fractionate tissue into submicron-size fragments. The objective of this work is to test the hypothesis experimentally that atomization and fountain formation occurs similarly in liquids and tissues and results in tissue erosion. A 2-MHz HIFU transducer operating at peak in situ pressures of 50 MPa and-11 MPa (intensity = 14 kW/cm2) was focused at the interface between a liquid or tissue and air. A high-speed camera was used to monitor atomization and fountain formation in water, ethanol, glycerol, bovine liver, and porcine blood clots. The in situ intensity threshold for consistent atomization in one 10-ms pulse increased in the order: ethanol (180 W/cm2) < blood clot (250 W/cm2) < water (350 W/cm2) < liver (6200 W/cm2); glycerol did not atomize. Average jet velocities for the initial spray at the maximum acoustic intensity were similar for all materials and on the order of 20 m/s. The tissue erosion rate of liver approached saturation at around 300 10-ms pulses repeated at 1 Hz, which had an average erosion volume of 25.7±10.9 mm3. While tissue atomization and fountain formation does not completely mimic what is observed in liquids, atomization provides a plausible explanation of how tissue is fractionated in millisecond boiling and possibly even cavitation cloud histotrispy therapies.

Original languageEnglish (US)
Title of host publication2012 IEEE International Ultrasonics Symposium, IUS 2012
Pages1003-1006
Number of pages4
DOIs
StatePublished - Dec 1 2012
Event2012 IEEE International Ultrasonics Symposium, IUS 2012 - Dresden, Germany
Duration: Oct 7 2012Oct 10 2012

Publication series

NameIEEE International Ultrasonics Symposium, IUS
ISSN (Print)1948-5719
ISSN (Electronic)1948-5727

Other

Other2012 IEEE International Ultrasonics Symposium, IUS 2012
CountryGermany
CityDresden
Period10/7/1210/10/12

Fingerprint

atomizing
cavitation flow
liquid atomization
liver
boiling
erosion
bubbles
glycerols
blood
therapy
ethyl alcohol
capillary waves
high speed cameras
liquids
pulses
water
sprayers
transducers
fragments
saturation

All Science Journal Classification (ASJC) codes

  • Acoustics and Ultrasonics

Cite this

Simon, J., Sapozhnikov, O., Khokhlova, V., Wang, Y. N., Crum, L., & Bailey, M. (2012). Tissue atomization by high intensity focused ultrasound. In 2012 IEEE International Ultrasonics Symposium, IUS 2012 (pp. 1003-1006). [6562285] (IEEE International Ultrasonics Symposium, IUS). https://doi.org/10.1109/ULTSYM.2012.0251
Simon, Julianna ; Sapozhnikov, Oleg ; Khokhlova, Vera ; Wang, Yak Nam ; Crum, Lawrence ; Bailey, Michael. / Tissue atomization by high intensity focused ultrasound. 2012 IEEE International Ultrasonics Symposium, IUS 2012. 2012. pp. 1003-1006 (IEEE International Ultrasonics Symposium, IUS).
@inproceedings{d6bbcb5546cd4d509a667986bf8cb403,
title = "Tissue atomization by high intensity focused ultrasound",
abstract = "Liquid atomization and fountain formation by focused ultrasound was first published by Wood and Loomis [1]. Since then, the cavitation-wave hypothesis emerged to explain atomization in a fountain, which states atomization arises from a combination of surface capillary waves and the collapse of cavitation bubbles. More recently, high intensity focused ultrasound (HIFU) has been shown to fractionate tissue through either pulsed-cavitation or millisecond boiling histotripsy therapies; however it is unclear how millimeter-size boiling bubbles or cavitation bubble clouds fractionate tissue into submicron-size fragments. The objective of this work is to test the hypothesis experimentally that atomization and fountain formation occurs similarly in liquids and tissues and results in tissue erosion. A 2-MHz HIFU transducer operating at peak in situ pressures of 50 MPa and-11 MPa (intensity = 14 kW/cm2) was focused at the interface between a liquid or tissue and air. A high-speed camera was used to monitor atomization and fountain formation in water, ethanol, glycerol, bovine liver, and porcine blood clots. The in situ intensity threshold for consistent atomization in one 10-ms pulse increased in the order: ethanol (180 W/cm2) < blood clot (250 W/cm2) < water (350 W/cm2) < liver (6200 W/cm2); glycerol did not atomize. Average jet velocities for the initial spray at the maximum acoustic intensity were similar for all materials and on the order of 20 m/s. The tissue erosion rate of liver approached saturation at around 300 10-ms pulses repeated at 1 Hz, which had an average erosion volume of 25.7±10.9 mm3. While tissue atomization and fountain formation does not completely mimic what is observed in liquids, atomization provides a plausible explanation of how tissue is fractionated in millisecond boiling and possibly even cavitation cloud histotrispy therapies.",
author = "Julianna Simon and Oleg Sapozhnikov and Vera Khokhlova and Wang, {Yak Nam} and Lawrence Crum and Michael Bailey",
year = "2012",
month = "12",
day = "1",
doi = "10.1109/ULTSYM.2012.0251",
language = "English (US)",
isbn = "9781467345613",
series = "IEEE International Ultrasonics Symposium, IUS",
pages = "1003--1006",
booktitle = "2012 IEEE International Ultrasonics Symposium, IUS 2012",

}

Simon, J, Sapozhnikov, O, Khokhlova, V, Wang, YN, Crum, L & Bailey, M 2012, Tissue atomization by high intensity focused ultrasound. in 2012 IEEE International Ultrasonics Symposium, IUS 2012., 6562285, IEEE International Ultrasonics Symposium, IUS, pp. 1003-1006, 2012 IEEE International Ultrasonics Symposium, IUS 2012, Dresden, Germany, 10/7/12. https://doi.org/10.1109/ULTSYM.2012.0251

Tissue atomization by high intensity focused ultrasound. / Simon, Julianna; Sapozhnikov, Oleg; Khokhlova, Vera; Wang, Yak Nam; Crum, Lawrence; Bailey, Michael.

2012 IEEE International Ultrasonics Symposium, IUS 2012. 2012. p. 1003-1006 6562285 (IEEE International Ultrasonics Symposium, IUS).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

TY - GEN

T1 - Tissue atomization by high intensity focused ultrasound

AU - Simon, Julianna

AU - Sapozhnikov, Oleg

AU - Khokhlova, Vera

AU - Wang, Yak Nam

AU - Crum, Lawrence

AU - Bailey, Michael

PY - 2012/12/1

Y1 - 2012/12/1

N2 - Liquid atomization and fountain formation by focused ultrasound was first published by Wood and Loomis [1]. Since then, the cavitation-wave hypothesis emerged to explain atomization in a fountain, which states atomization arises from a combination of surface capillary waves and the collapse of cavitation bubbles. More recently, high intensity focused ultrasound (HIFU) has been shown to fractionate tissue through either pulsed-cavitation or millisecond boiling histotripsy therapies; however it is unclear how millimeter-size boiling bubbles or cavitation bubble clouds fractionate tissue into submicron-size fragments. The objective of this work is to test the hypothesis experimentally that atomization and fountain formation occurs similarly in liquids and tissues and results in tissue erosion. A 2-MHz HIFU transducer operating at peak in situ pressures of 50 MPa and-11 MPa (intensity = 14 kW/cm2) was focused at the interface between a liquid or tissue and air. A high-speed camera was used to monitor atomization and fountain formation in water, ethanol, glycerol, bovine liver, and porcine blood clots. The in situ intensity threshold for consistent atomization in one 10-ms pulse increased in the order: ethanol (180 W/cm2) < blood clot (250 W/cm2) < water (350 W/cm2) < liver (6200 W/cm2); glycerol did not atomize. Average jet velocities for the initial spray at the maximum acoustic intensity were similar for all materials and on the order of 20 m/s. The tissue erosion rate of liver approached saturation at around 300 10-ms pulses repeated at 1 Hz, which had an average erosion volume of 25.7±10.9 mm3. While tissue atomization and fountain formation does not completely mimic what is observed in liquids, atomization provides a plausible explanation of how tissue is fractionated in millisecond boiling and possibly even cavitation cloud histotrispy therapies.

AB - Liquid atomization and fountain formation by focused ultrasound was first published by Wood and Loomis [1]. Since then, the cavitation-wave hypothesis emerged to explain atomization in a fountain, which states atomization arises from a combination of surface capillary waves and the collapse of cavitation bubbles. More recently, high intensity focused ultrasound (HIFU) has been shown to fractionate tissue through either pulsed-cavitation or millisecond boiling histotripsy therapies; however it is unclear how millimeter-size boiling bubbles or cavitation bubble clouds fractionate tissue into submicron-size fragments. The objective of this work is to test the hypothesis experimentally that atomization and fountain formation occurs similarly in liquids and tissues and results in tissue erosion. A 2-MHz HIFU transducer operating at peak in situ pressures of 50 MPa and-11 MPa (intensity = 14 kW/cm2) was focused at the interface between a liquid or tissue and air. A high-speed camera was used to monitor atomization and fountain formation in water, ethanol, glycerol, bovine liver, and porcine blood clots. The in situ intensity threshold for consistent atomization in one 10-ms pulse increased in the order: ethanol (180 W/cm2) < blood clot (250 W/cm2) < water (350 W/cm2) < liver (6200 W/cm2); glycerol did not atomize. Average jet velocities for the initial spray at the maximum acoustic intensity were similar for all materials and on the order of 20 m/s. The tissue erosion rate of liver approached saturation at around 300 10-ms pulses repeated at 1 Hz, which had an average erosion volume of 25.7±10.9 mm3. While tissue atomization and fountain formation does not completely mimic what is observed in liquids, atomization provides a plausible explanation of how tissue is fractionated in millisecond boiling and possibly even cavitation cloud histotrispy therapies.

UR - http://www.scopus.com/inward/record.url?scp=84882435865&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84882435865&partnerID=8YFLogxK

U2 - 10.1109/ULTSYM.2012.0251

DO - 10.1109/ULTSYM.2012.0251

M3 - Conference contribution

AN - SCOPUS:84882435865

SN - 9781467345613

T3 - IEEE International Ultrasonics Symposium, IUS

SP - 1003

EP - 1006

BT - 2012 IEEE International Ultrasonics Symposium, IUS 2012

ER -

Simon J, Sapozhnikov O, Khokhlova V, Wang YN, Crum L, Bailey M. Tissue atomization by high intensity focused ultrasound. In 2012 IEEE International Ultrasonics Symposium, IUS 2012. 2012. p. 1003-1006. 6562285. (IEEE International Ultrasonics Symposium, IUS). https://doi.org/10.1109/ULTSYM.2012.0251